SCHEMBL9058443

SCHEMBL9058443

COc1ccc2c(c1)[C@H](c1cccc3ccccc13)O[C@@H](CC(=O)N1CCCC(C(=O)O)C1)C(=O)N2CC(C)(C)C

nearest known ligand 0.51

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
FDFT1 P37268 10/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8684372 1.00 FDFT1 (0.51) FDFT1
SCHEMBL9058402 0.92 FDFT1 (0.60) FDFT1
SCHEMBL8684122 0.92 FDFT1 (0.60) FDFT1
SCHEMBL9057178 0.91 FDFT1 (0.48) FDFT1
SCHEMBL7236711 0.91 FDFT1 (0.56) FDFT1
SCHEMBL7236721 0.91 FDFT1 (0.56) FDFT1
SCHEMBL8684184 0.91 FDFT1 (0.48) FDFT1
SCHEMBL8684542 0.90 FDFT1 (0.57) FDFT1
SCHEMBL8683940 0.90 FDFT1 (0.57) FDFT1
SCHEMBL8683964 0.89 FDFT1 (0.47) FDFT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1996020184-A1 NAPHTHYL-BENZOXAZEPINES OR -BENZOTHIAZEPINES AS SQUALENE SYNTHETASE INHIBITORS PFIZER INC. (US) 1996-07-04 WO claimed
WO-1996020184-A1 NAPHTHYL-BENZOXAZEPINES OR -BENZOTHIAZEPINES AS SQUALENE SYNTHETASE INHIBITORS PFIZER INC. (US) 1996-07-04 WO disclosed