SCHEMBL9060795

SCHEMBL9060795

CCCCC[C@H]1CC[C@H](c2ccc(OC(F)(F)F)cc2)CC1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 1/20 0.44
RCOR1 Q9UKL0 1/20 0.44
CYP2C9 P11712 1/20 0.43
MAPT P10636 2/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
ALDH1A1 P00352 1/20 0.41
LMNA P02545 1/20 0.41
MAPK1 P28482 1/20 0.41
SPHK1 Q9NYA1 3/20 0.40
HDAC3 O15379 1/20 0.39
HDAC1 Q13547 1/20 0.39
HDAC2 Q92769 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
ESR2 Q92731 1/20 0.39
SLC6A4 P31645 1/20 0.38
SLC6A3 Q01959 1/20 0.38
RAB9A P51151 1/20 0.38
TSHR P16473 1/20 0.38
GAA P10253 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5343315 1.00 KDM1A (0.44) KDM1ARCOR1CYP2C9MAPTMEN1
SCHEMBL9061236 0.99 KDM1A (0.43) KDM1ARCOR1CYP2C9MAPTMEN1
SCHEMBL9061600 0.99 KDM1A (0.43) KDM1ARCOR1CYP2C9MAPTMEN1
SCHEMBL9061141 0.99 KDM1A (0.43) KDM1ARCOR1CYP2C9MAPTMEN1
SCHEMBL9062142 0.99 KDM1A (0.43) KDM1ARCOR1CYP2C9MAPTMEN1
SCHEMBL9061228 0.99 KDM1A (0.43) KDM1ARCOR1CYP2C9MAPTMEN1
SCHEMBL9062145 0.99 KDM1A (0.43) KDM1ARCOR1CYP2C9MAPTMEN1
SCHEMBL9061593 0.99 KDM1A (0.43) KDM1ARCOR1CYP2C9MAPTMEN1
SCHEMBL9062288 0.99 KDM1A (0.43) KDM1ARCOR1CYP2C9MAPTMEN1
SCHEMBL9061135 0.99 KDM1A (0.43) KDM1ARCOR1CYP2C9MAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0334911-B1 SUBSTITUTED PHENYLTRIFLUORMETHYLETHERS MERCK PATENT GmbH (DE) 1993-02-10 EP claimed
US-5536442-A ELECTROOPTICS MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1996-07-16 US disclosed
US-5324449-A Substituted phenyl trifluoromethyl ethers MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1994-06-28 US disclosed
EP-0334911-B1 SUBSTITUTED PHENYLTRIFLUORMETHYLETHERS MERCK PATENT GmbH (DE) 1993-02-10 EP disclosed
EP-0334911-A1 SUBSTITUTED PHENYLTRIFLUORMETHYLETHERS MERCK PATENT GmbH (DE) 1989-10-04 EP disclosed