⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9063292 | 0.82 | — | — | |
| SCHEMBL9062428 | 0.80 | — | — | |
| SCHEMBL11588702 | 0.78 | SPHK2 (0.52) | — | |
| SCHEMBL11590254 | 0.78 | SPHK2 (0.52) | — | |
| SCHEMBL9062425 | 0.78 | SPHK2 (0.52) | — | |
| SCHEMBL19197699 | 0.78 | SPHK2 (0.52) | — | |
| SCHEMBL640653 | 0.75 | — | — | |
| SCHEMBL3808409 | 0.75 | — | — | |
| SCHEMBL24933469 | 0.75 | HSD17B10 (0.33) | — | |
| SCHEMBL1938703 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0531219-B1 | Use of histamine derivatives for the preparation of drugs, new histamine derivatives and drugs | BIOPROJET SOC CIV (FR) | 1995-12-06 | — | — | EP | claimed |
| EP-0385038-B1 | ORTHO-SUBSTITUTED PHENYL AMIDINE AND PHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM | The Boots Company PLC (GB) | 1993-06-02 | — | — | EP | claimed |
| EP-0385038-A1 | Ortho-substituted phenyl amidine and phenyl guanidine derivatives and antidiabetic or hypoglycaemic agents containing them | The Boots Company PLC (GB) | 1990-09-05 | — | — | EP | claimed |
| CN-113365627-A | VDAC inhibitors for the treatment of inflammatory bowel disease | 国家生物技术研究所公司 | 2021-09-07 | — | — | CN | disclosed |
| CN-113347973-A | VDAC inhibitors for the treatment of autoimmune diseases | 国家生物技术研究所公司 | 2021-09-03 | — | — | CN | disclosed |
| WO-2021158481-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA, INC. (US) | 2021-08-12 | — | — | WO | disclosed |
| WO-2020247546-A1 | ADENOSINE ANALOGS FOR THE TREATMENT OF DISEASE | BIOINTERVENE, INC. (US) | 2020-12-10 | — | — | WO | disclosed |
| US-8093258-B2 | Use of urokinase inhibitors for the treatment and/or prevention of neuropathological diseases | WILEX AG (DE) | 2012-01-10 | — | — | US | disclosed |
| US-20100222380-A1 | Modified Chalcone Compounds as Antimitotic Agents | ARIZONA BIOMEDICAL RESEARCH COMMISSION (US) | 2010-09-02 | — | — | US | disclosed |
| US-7714025-B2 | Modified chalcone compounds as antimitotic agents | ARIZONA BIOMEDICAL RESEARCH COMMISSION (US) | 2010-05-11 | — | — | US | disclosed |
| US-20090069251-A1 | Use Of Urokinase Inhibitors for the Treatment and/or Prevention of Neuropathological Diseases | WILEX AG (DE) | 2009-03-12 | — | — | US | disclosed |
| US-20070265317-A1 | MODIFIED CHALCONE COMPOUNDS AS ANTIMITOTIC AGENTS | ARIZONA BIOMEDICAL RESEARCH COMMISSION (US) | 2007-11-15 | — | — | US | disclosed |
| EP-1644343-B1 | 5-SUBSTITUTED QUINAZOLINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2007-07-04 | — | — | EP | disclosed |
| WO-1996017612-A1 | USE OF SUBSTITUTED PHENYLAMIDINE AND PHENYLGUANIDINE COMPOUNDS FOR THE TREATMENT OF CEREBRAL AND CARDIAC ISCHAEMIA, CONVULSION AND SICKLE CELL ANAEMIA | KNOLL AKTIENGESELLSCHAFT (DE) | 1996-06-13 | — | — | WO | disclosed |
| EP-0531219-B1 | Use of histamine derivatives for the preparation of drugs, new histamine derivatives and drugs | BIOPROJET SOC CIV (FR) | 1995-12-06 | — | — | EP | disclosed |
| US-5373008-A | Phenylamidine and phenylguanidine derivatives and their use as anti-diabetic agents | THE BOOTS COMPANT PLC. (GB) | 1994-12-13 | — | — | US | disclosed |
| US-5223498-A | Hypoglycemic agents | THE BOOTS COMPANY PLC (GB) | 1993-06-29 | — | — | US | disclosed |
| EP-0385038-B1 | ORTHO-SUBSTITUTED PHENYL AMIDINE AND PHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM | The Boots Company PLC (GB) | 1993-06-02 | — | — | EP | disclosed |
| EP-0385038-A1 | Ortho-substituted phenyl amidine and phenyl guanidine derivatives and antidiabetic or hypoglycaemic agents containing them | The Boots Company PLC (GB) | 1990-09-05 | — | — | EP | disclosed |