SCHEMBL906337

SCHEMBL906337

[CH2]Cc1cncn1C

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL178520 0.83
Hydrochloric Acid SCHEMBL27926323 0.81
SCHEMBL4300091 0.79
SCHEMBL12722883 0.79
SCHEMBL25404428 0.77
SCHEMBL20245292 0.76
SCHEMBL240920 0.76
SCHEMBL451875 0.76
SCHEMBL5262990 0.76
SCHEMBL8864900 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1294699-B1 MODULATORS OF TNF- ALPHA SIGNALLING GENZYME CORP (US) 2016-04-13 EP claimed
US-8518999-B2 Modulators of TNF-αsignaling GENZYME CORPORATION (US) 2013-08-27 US claimed
CN-100494182-C Regulatory factor of tumor necrosis alpha factor GENZYME CORP (US) 2009-06-03 CN claimed
EP-1420747-A2 BENZOQUINONE ANSAMYCINS Kosan Biosciences, Inc. (US) 2004-05-26 EP claimed
CN-1441787-A Modulators of TNF-alpha signaling GENZYME CORP (US) 2003-09-10 CN claimed
US-20030114450-A1 Anticancer agents; antiproliferative agent KOSAN BIOSCIENCES, INC. 2003-06-19 US claimed
WO-2003013430-A2 BENZOQUINONE ANSAMYCINS KOSAN BIOSCIENCES, INC. (US) 2003-02-20 WO claimed
JP-H09503518-A 1997-04-08 JP claimed
EP-0722447-A1 3-PYRROLIDINYLTHIO-CARBAPENEM DERIVATIVES AND THEIR ANTIMICROBAL ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-07-24 EP claimed
WO-1995010520-A1 3-PYRROLIDINYLTHIO-CARBAPENEM DERIVATIVES AND THEIR ANTIMICROBAL ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1995-04-20 WO claimed
US-20150038541-A1 COMPOSITION AND METHODS FOR CELL MODULATION APOSIGNAL BIOSCIENCE LLC (US) 2015-02-05 US disclosed
EP-2827861-A1 COMPOSITION AND METHODS FOR CELL MODULATION Aposignal Bioscience LLC (US) 2015-01-28 EP disclosed
WO-2013142376-A1 COMPOSITION AND METHODS FOR CELL MODULATION APOSIGNAL BIOSCIENCE LLC (US) 2013-09-26 WO disclosed
EP-2243033-B1 THERMAL DENATURATION SCREENING ASSAY TO IDENTIFY CANDIDATE COMPOUNDS FOR PREVENTION AND TREATMENT OF PARKINSON'S DISEASE ELAN PHARMA INT LTD (IE) 2012-06-06 EP disclosed
EP-2276482-A2 HSP90 INHIBITORS OR MODULATORS FOR TREATMENT OR PREVENTION OF SUBSTANCE-RELATED DISORDERS The Regents of the University of California (US) 2011-01-26 EP disclosed
EP-0004466-B1 DEMETHYL MAYTANSINOIDS AND METHODS FOR PRODUCING THEM Takeda Chemical Industries, Ltd. (JP) 1982-01-27 EP disclosed
US-4307016-A FUNGICIDES, PROTOZOACIDES OR ANTITUMOR AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1981-12-22 US disclosed
US-4294757-A BLEACHING CELLULOSE FIBERS AND ADDITION OF ALKALI METAL POLYPHOSPHATES AND ALKALI METAL DIETHYLENETRIAMINE PENTA(METHYLENE PHOSPHONAT) TAKEDA CHEMICAL INDUSTRIES, LTD (JP) 1981-10-13 US disclosed
EP-0014402-A1 Novel 20-0-acylmaytansinoids, process for their preparation and pharmaceutical compositions containing them Takeda Chemical Industries, Ltd. (JP) 1980-08-20 EP disclosed
EP-0004466-A1 Demethyl maytansinoids and methods for producing them Takeda Chemical Industries, Ltd. (JP) 1979-10-03 EP disclosed