Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 20/20 | 0.65 |
| ▸ | GRM1 | Q13255 | 20/20 | 0.65 |
| ▸ | HTR2B | P41595 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12204830 | 0.89 | GRM5 (0.52) | GRM5GRM1HTR2B | |
| SCHEMBL1635758 | 0.88 | GRM5 (0.71) | GRM5GRM1HTR2B | |
| SCHEMBL8004796 | 0.80 | GRM5 (0.82) | GRM5GRM1HTR2B | |
| SCHEMBL8006252 | 0.80 | GRM5 (0.82) | GRM5GRM1HTR2B | |
| Hydrochloric Acid SCHEMBL2481388 | 0.79 | GRM5 (1.00) | GRM5GRM1HTR2B | |
| Hydrochloric Acid SCHEMBL906758 | 0.79 | GRM5 (0.83) | GRM5GRM1HTR2B | |
| Hydrochloric Acid SCHEMBL906518 | 0.79 | GRM5 (0.81) | GRM5GRM1HTR2B | |
| SCHEMBL906668 | 0.78 | GRM5 (0.46) | GRM5GRM1HTR2B | |
| SCHEMBL1637883 | 0.76 | GRM5 (0.57) | GRM5GRM1HTR2B | |
| SCHEMBL906671 | 0.73 | GRM5 (0.41) | GRM5GRM1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276759-B1 | 3-INDAZOLYL-4-PYRIDYLISOTHIAZOLES | LILLY CO ELI (US) | 2011-10-19 | — | — | EP | disclosed |
| US-7932274-B2 | 3-indazolyl-4-pyridylisothiazoles | ELI LILLY AND COMPANY (US) | 2011-04-26 | — | — | US | disclosed |
| EP-2276759-A1 | 3-INDAZOLYL-4-PYRIDYLISOTHIAZOLES | Eli Lilly & Company (US) | 2011-01-26 | — | — | EP | disclosed |