Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 19/20 | 0.84 |
| ▸ | KDR | P35968 | 17/20 | 0.84 |
| ▸ | EPHB4 | P54760 | 15/20 | 0.84 |
| ▸ | FLT1 | P17948 | 4/20 | 0.84 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.74 |
| ▸ | EGFR | P00533 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL906784 | 1.00 | EPHA2 (0.84) | EPHA2KDREPHB4FLT1ERBB2 | |
| SCHEMBL1225511 | 0.91 | EPHA2 (1.00) | EPHA2KDREPHB4FLT1ERBB2 | |
| SCHEMBL1225512 | 0.91 | EPHA2 (1.00) | EPHA2KDREPHB4FLT1ERBB2 | |
| SCHEMBL1793275 | 0.91 | EPHA2 (1.00) | EPHA2KDREPHB4FLT1ERBB2 | |
| SCHEMBL1225510 | 0.91 | EPHA2 (1.00) | EPHA2KDREPHB4FLT1ERBB2 | |
| Hydrochloric Acid SCHEMBL906901 | 0.91 | EPHA2 (0.98) | EPHA2KDREPHB4FLT1ERBB2 | |
| Hydrochloric Acid SCHEMBL906899 | 0.91 | EPHA2 (0.98) | EPHA2KDREPHB4FLT1ERBB2 | |
| Hydrochloric Acid SCHEMBL906902 | 0.91 | EPHA2 (0.98) | EPHA2KDREPHB4FLT1ERBB2 | |
| SCHEMBL4461385 | 0.87 | EPHA2 (0.79) | EPHA2KDREPHB4FLT1ERBB2 | |
| SCHEMBL4461387 | 0.87 | EPHA2 (0.79) | EPHA2KDREPHB4FLT1ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2277867-A2 | Compounds, pharmaceutical compositions thereof and their use in treating cancer | Symphony Evolution, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |