Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 7/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20364255 | 1.00 | CA1 (0.50) | CA1CA2CA4CA7GAA | |
| SCHEMBL9068343 | 1.00 | CA1 (0.50) | CA1CA2CA4CA7GAA | |
| SCHEMBL8588938 | 0.85 | HPGD (0.50) | CA1CA2CA4CA7GAA | |
| SCHEMBL8588896 | 0.85 | HPGD (0.50) | CA1CA2CA4CA7GAA | |
| SCHEMBL3941336 | 0.84 | CA1 (0.53) | CA1CA2CA4CA7GAA | |
| SCHEMBL3941339 | 0.84 | CA1 (0.53) | CA1CA2CA4CA7GAA | |
| SCHEMBL20893356 | 0.84 | CA1 (0.53) | CA1CA2CA4CA7GAA | |
| SCHEMBL9068333 | 0.83 | CA1 (0.52) | CA1CA2CA4CA7GAA | |
| SCHEMBL15047078 | 0.83 | CA1 (0.52) | CA1CA2CA4CA7GAA | |
| SCHEMBL4549470 | 0.83 | CA1 (0.49) | CA1CA2CA4CA7GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5506228-A | 2,6-diaryl pyridazinones with immunosuppressant activity | MERCK & CO., INC. (US) | 1996-04-09 | — | — | US | disclosed |
| EP-0022906-B1 | PROCESS FOR THE PREPARATION OF PYRAZOLE DERIVATIVES | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-08-08 | — | — | EP | disclosed |
| EP-0022906-A1 | Process for the preparation of pyrazole derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1981-01-28 | — | — | EP | disclosed |