Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 5/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2667478 | 0.94 | GCK (0.55) | GCKKCNH2HRH3ALDH1A1ADORA2A | |
| SCHEMBL9070910 | 0.94 | GCK (0.57) | GCKKCNH2HRH3ALDH1A1ADORA2A | |
| SCHEMBL2667778 | 0.92 | GCK (0.49) | GCKKCNH2HRH3ALDH1A1ADORA2A | |
| SCHEMBL9070990 | 0.90 | GCK (0.60) | GCKKCNH2ALDH1A1RAB9ANPC1 | |
| SCHEMBL2667481 | 0.86 | F2 (0.42) | GCKKCNH2HRH3 | |
| SCHEMBL2667346 | 0.85 | GCK (0.56) | GCKKCNH2 | |
| SCHEMBL2667475 | 0.85 | GCK (0.51) | GCKHRH3 | |
| SCHEMBL2668003 | 0.84 | GCK (0.68) | GCKKCNH2RAB9ANPC1 | |
| SCHEMBL2667638 | 0.84 | GCK (0.66) | GCKKCNH2RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL2667980 | 0.84 | GCK (0.47) | GCKALDH1A1ADORA2ARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009083553-A1 | AZINE COMPOUNDS AS GLUCOKINASE ACTIVATORS | RHEOSCIENCE A/S (DK) | 2009-07-09 | — | — | WO | disclosed |