Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 19/20 | 0.53 |
| ▸ | RARA | P10276 | 3/20 | 0.53 |
| ▸ | RARB | P10826 | 3/20 | 0.53 |
| ▸ | RARG | P13631 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5451958 | 0.91 | GCK (0.65) | GCKRARARARBRARG | |
| SCHEMBL2650573 | 0.83 | GCK (0.54) | GCKRARARARBRARGNPC1 | |
| SCHEMBL2666296 | 0.81 | GCK (0.77) | GCKRARARARBRARG | |
| SCHEMBL5419201 | 0.77 | GCK (0.68) | GCKRARARARBRARG | |
| SCHEMBL14505783 | 0.76 | GCK (0.71) | GCKRARARARBRARG | |
| SCHEMBL14505768 | 0.73 | GCK (0.61) | GCKRARARARBRARG | |
| SCHEMBL2651412 | 0.73 | GCK (0.63) | GCKRARARARBRARG | |
| SCHEMBL841204 | 0.70 | MAPT (0.55) | — | |
| SCHEMBL14811955 | 0.70 | MEN1 (0.44) | NPC1 | |
| SCHEMBL14190698 | 0.70 | GCK (0.59) | GCKRARARARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003000267-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | ASTRAZENECA AB (SE) | 2003-01-03 | — | — | WO | disclosed |