⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6301548 | 0.76 | — | — | |
| SCHEMBL2268175 | 0.74 | — | — | |
| SCHEMBL1469716 | 0.73 | — | — | |
| SCHEMBL18191302 | 0.73 | — | — | |
| SCHEMBL10769432 | 0.71 | — | — | |
| SCHEMBL610481 | 0.69 | — | — | |
| SCHEMBL10295068 | 0.69 | — | — | |
| SCHEMBL9482068 | 0.69 | — | — | |
| SCHEMBL8594072 | 0.69 | — | — | |
| SCHEMBL132011 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 102 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230390303-A1 | CANCER TREATMENT BY COMBINATION OF EP4 ANTAGONIST AND IMMUNE CHECKPOINT INHIBITOR | ONO PHARMACEUTICAL CO., LTD. (JP) | 2023-12-07 | — | — | US | disclosed |
| EP-4245301-A1 | CANCER TREATMENT BY COMBINED USE OF EP4 ANTAGONIST AND IMMUNE CHECKPOINT INHIBITOR | ONO Pharmaceutical Co., Ltd. (JP) | 2023-09-20 | — | — | EP | disclosed |
| US-20220048881-A1 | TRICYCLIC SPIRO COMPOUND | ONO PHARMACEUTICAL CO., LTD. (JP) | 2022-02-17 | — | — | US | disclosed |
| US-11192876-B2 | Tricyclic spiro compound | ONO PHARMACEUTICAL CO., LTD. (JP) | 2021-12-07 | — | — | US | disclosed |
| EP-3482760-B1 | COMBINATION COMPRISING EP4 ANTAGONIST AND IMMUNE CHECKPOINT INHIBITOR | ONO PHARMACEUTICAL CO (JP) | 2021-11-10 | — | — | EP | disclosed |
| US-11065226-B2 | Combination comprising EP4 antagonist and immune checkpoint inhibitor | ONO PHARMACEUTICAL CO., LTD. (JP) | 2021-07-20 | — | — | US | disclosed |
| EP-3778562-A1 | TRICYCLIC SPIRO COMPOUND | ONO Pharmaceutical Co., Ltd. (JP) | 2021-02-17 | — | — | EP | disclosed |
| CN-111039916-A | Tricyclic spiro compounds | 小野药品工业株式会社 | 2020-04-21 | — | — | CN | disclosed |
| US-20200102284-A1 | TRICYCLIC SPIRO COMPOUND | ONO PHARMACEUTICAL CO., LTD. (JP) | 2020-04-02 | — | — | US | disclosed |
| US-10538502-B2 | Tricyclic spiro compound | ONO PHARMACEUTICAL CO., LTD. (JP) | 2020-01-21 | — | — | US | disclosed |
| CN-1312804-A | Macrocyclic analogs and methods of their use and preparation | EISAI CO LTD (JP) | 2001-09-12 | — | — | CN | disclosed |
| CN-1293674-A | Triazolo gerivatives and chemokine inhibitors containing the same as the active ingredient | TORAY INDUSTRIES (JP) | 2001-05-02 | — | — | CN | disclosed |
| US-6214865-B1 | Macrocyclic analogs and methods of their use and preparation | EISAI CO., LTD. (JP) | 2001-04-10 | — | — | US | disclosed |
| EP-1087960-A1 | MACROCYCLIC ANALOGS AND METHODS OF THEIR USE AND PREPARATION | EISAI CO., LTD. (JP) | 2001-04-04 | — | — | EP | disclosed |
| EP-1067130-A1 | TRIAZOLO DERIVATIVES AND CHEMOKINE INHIBITORS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | TORAY INDUSTRIES, INC. (JP) | 2001-01-10 | — | — | EP | disclosed |
| WO-1999065894-A1 | MACROCYCLIC ANALOGS AND METHODS OF THEIR USE AND PREPARATION | EISAI CO., LTD. (JP) | 1999-12-23 | — | — | WO | disclosed |
| US-5786367-A | OXYGEN SCAVENGERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-07-28 | — | — | US | disclosed |
| CN-1130377-A | Cyclic amide derivatives | OTSUKA PHARMA CO LTD (JP) | 1996-09-04 | — | — | CN | disclosed |
| EP-0719258-A1 | CYCLIC AMIDE DERIVATIVES FOR PROTECTING AGAINST ULTRAVIOLET RAYS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-07-03 | — | — | EP | disclosed |
| WO-1996002508-A1 | CYCLIC AMIDE DERIVATIVES FOR PROTECTING AGAINST ULTRAVIOLET RAYS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-02-01 | — | — | WO | disclosed |