Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 5/20 | 0.70 |
| ▸ | FNTB | P49356 | 5/20 | 0.70 |
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 10/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.42 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.42 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9074179 | 1.00 | FNTA (0.70) | FNTAFNTBKLK7BACE1ACE | |
| SCHEMBL9070335 | 0.94 | FNTA (0.63) | FNTAFNTBKLK7BACE1REN | |
| SCHEMBL9070336 | 0.94 | FNTA (0.63) | FNTAFNTBKLK7BACE1REN | |
| SCHEMBL8330649 | 0.83 | FNTA (1.00) | FNTAFNTBBACE1ACE | |
| SCHEMBL8333489 | 0.82 | FNTA (0.72) | FNTAFNTBKLK7BACE1KLK5 | |
| SCHEMBL8333486 | 0.82 | FNTA (0.72) | FNTAFNTBKLK7BACE1KLK5 | |
| SCHEMBL8368594 | 0.82 | FNTA (0.72) | FNTAFNTBKLK7BACE1KLK5 | |
| SCHEMBL6056534 | 0.80 | FNTA (0.58) | FNTAFNTB | |
| SCHEMBL6056526 | 0.80 | FNTA (0.58) | FNTAFNTB | |
| SCHEMBL9068027 | 0.80 | FNTA (0.58) | FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5585359-A | LACK OF THIOL MOIETY PREVENTS THIOL-DEPENDENT CHEMICAL REACTIONS AND REDUCES SYSTEMIC TOXICITY | MERCK & CO., INC. (US) | 1996-12-17 | — | — | US | disclosed |