Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glycinebetaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.39 |
| ▸ | CPT2 | P23786 | 1/20 | 0.38 |
| ▸ | CPT1A | P50416 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CRAT | P43155 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycinebetaine SCHEMBL7147184 | 0.88 | TSHR (0.46) | TP53SLC22A16TSHRALDH1A1LMNA | |
| Glycinebetaine SCHEMBL1846390 | 0.88 | SLC22A16 (0.50) | SLC22A16TSHRALDH1A1LMNAAPEX1 | |
| Glycinebetaine SCHEMBL273227 | 0.84 | CPT2 (0.45) | SLC22A16TSHRALDH1A1LMNAAPEX1 | |
| Glycinebetaine SCHEMBL9281697 | 0.83 | TSHR (0.55) | SLC22A16TSHRALDH1A1LMNAAPEX1 | |
| Glycinebetaine SCHEMBL6135201 | 0.83 | CPT2 (0.44) | SLC22A16TSHRALDH1A1LMNAAPEX1 | |
| Glycinebetaine SCHEMBL7739 | 0.83 | — | — | |
| Glycinebetaine SCHEMBL2803780 | 0.83 | TSHR (0.53) | SLC22A16TSHRALDH1A1LMNAAPEX1 | |
| Betaine SCHEMBL31467313 | 0.83 | — | — | |
| Glycinebetaine SCHEMBL4900209 | 0.83 | — | — | |
| Glycinebetaine SCHEMBL8678519 | 0.83 | TSHR (0.53) | SLC22A16TSHRALDH1A1LMNAAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996005805-A1 | COMPOSITION FOR TREATMENT OF SKIN BLISTERS | KAMME CARL (SE) | 1996-02-29 | — | — | WO | disclosed |