Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.39 |
| ▸ | FDPS | P14324 | 3/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8011593 | 1.00 | TSHR (0.44) | TSHRTHRBLMNADNM1OPRM1 | |
| SCHEMBL9732230 | 1.00 | TSHR (0.44) | TSHRTHRBLMNADNM1OPRM1 | |
| SCHEMBL9732622 | 1.00 | TSHR (0.44) | TSHRTHRBLMNADNM1OPRM1 | |
| SCHEMBL9732344 | 1.00 | TSHR (0.44) | TSHRTHRBLMNADNM1OPRM1 | |
| SCHEMBL9732557 | 1.00 | TSHR (0.44) | TSHRTHRBLMNADNM1OPRM1 | |
| SCHEMBL276723 | 0.97 | — | — | |
| SCHEMBL7696737 | 0.88 | TSHR (0.50) | TSHRTHRBLMNADNM1OPRM1 | |
| SCHEMBL3421738 | 0.88 | TSHR (0.50) | TSHRTHRBLMNADNM1OPRM1 | |
| SCHEMBL7700484 | 0.88 | TSHR (0.50) | TSHRTHRBLMNADNM1OPRM1 | |
| SCHEMBL1845697 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5534529-A | Substituted aromatic amides and ureas derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses | SANKYO COMPANY, LIMITED (JP) | 1996-07-09 | — | — | US | disclosed |
| EP-0632036-A2 | Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1995-01-04 | — | — | EP | disclosed |