⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL659116 | 1.00 | — | — | |
| SCHEMBL657546 | 1.00 | — | — | |
| SCHEMBL657547 | 1.00 | — | — | |
| SCHEMBL5549710 | 1.00 | — | — | |
| SCHEMBL659299 | 1.00 | — | — | |
| SCHEMBL5548794 | 1.00 | — | — | |
| SCHEMBL16321798 | 0.98 | — | — | |
| SCHEMBL14833275 | 0.98 | — | — | |
| SCHEMBL14833352 | 0.98 | — | — | |
| SCHEMBL16321799 | 0.98 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9453017-B2 | Antiviral therapies with phospholipase D inhibitors | VANDERBILT UNIVERSITY (US) | 2016-09-27 | — | — | US | claimed |
| EP-1682109-B1 | THE USE OF 1-AMINOCYCLOHEXANE DERIVATIVES TO MODIFY DEPOSITION OF FIBRILLOGENIC AS PEPTIDES IN AMYLOIDOPATHIES | MERZ PHARMA GMBH & CO KGAA (DE) | 2008-10-15 | — | — | EP | claimed |
| US-20060205822-A1 | 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect | FOREST LABORATORIES, INC. (US) | 2006-09-14 | — | — | US | claimed |
| US-20170319611-A1 | METHODS AND COMPOSITIONS COMPRISING AKT INHIBITORS AND/OR PHOSPHOLIPASE D INHIBITORS | UNIV VANDERBILT (US) | 2017-11-09 | — | — | US | disclosed |
| US-20170027885-A1 | 1-AMINOCYCLOHEXANE DERIVATIVES FOR THE TREATMENT OF COCHLEAR TINNITUS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2017-02-02 | — | — | US | disclosed |
| US-9498450-B2 | 1-aminocyclohexane derivatives for the treatment of cochlear tinnitus | MERZ PHARMA GMBH & CO. KGAA (DE) | 2016-11-22 | — | — | US | disclosed |
| US-9468610-B2 | 1-aminocyclohexane derivatives for the treatment of hearing loss | MERZ PHARMA GMBH & CO. KGAA (DE) | 2016-10-18 | — | — | US | disclosed |
| US-9453017-B2 | Antiviral therapies with phospholipase D inhibitors | VANDERBILT UNIVERSITY (US) | 2016-09-27 | — | — | US | disclosed |
| EP-2386299-B1 | 1-Amino-Alkylcyclohexane derivatives for use in the treatment of tinnitus associated with hearing loss | MERZ PHARMA GMBH & CO KGAA (DE) | 2016-07-13 | — | — | EP | disclosed |
| EP-2548552-B1 | Titration package for 1-amino-alkylcyclohexanes | MERZ PHARMA GMBH & CO KGAA (DE) | 2015-11-18 | — | — | EP | disclosed |
| US-20150025041-A1 | ANTIVIRAL THERAPIES WITH PHOSPHOLIPASE D INHIBITORS | VANDERBILT UNIVERSITY (US) | 2015-01-22 | — | — | US | disclosed |
| US-20090081259-A1 | 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-03-26 | — | — | US | disclosed |
| WO-2009033652-A1 | 1-AMINO-ALKYLCYCLOHEXANE DERIVATIVES FOR THE TREATMENT OF COCHLEAR TINNITUS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-03-19 | — | — | WO | disclosed |
| US-20070105961-A1 | 1-Amino-alkylcyclohexanes as 5-HT3 and neuronal nicotinic receptor antagonists | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-05-10 | — | — | US | disclosed |
| EP-1228052-B1 | 1-CYCLIC AMINO-ALKYLCYCLOHEXANE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE AS ANTICONVULSANTS | MERZ PHARMA GMBH & CO KGAA (DE) | 2007-05-02 | — | — | EP | disclosed |
| US-20060205822-A1 | 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect | FOREST LABORATORIES, INC. (US) | 2006-09-14 | — | — | US | disclosed |
| EP-1318800-B1 | 1-AMINO-ALKYLCYCLOHEXANES AS TRYPANOCIDAL AGENTS | MERZ PHARMA GMBH & CO KGAA (DE) | 2005-01-26 | — | — | EP | disclosed |
| US-6602862-B1 | 1-Amino-alkylcyclohexanes as trypanocidal agents | MERZ PHARMA GMBH & CO., KGAA (DE) | 2003-08-05 | — | — | US | disclosed |
| EP-1228052-A1 | 1-CYCLIC AMINO-ALKYLCYCLOHEXANE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE AS ANTICONVULSANTS | Merz Pharmaceuticals GmbH (DE) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001032640-A1 | 1-CYCLIC AMINO-ALKYLCYCLOHEXANE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE AS ANTICONVULSANTS | MERZ PHARMACEUTICALS GMBH (DE) | 2001-05-10 | — | — | WO | disclosed |