Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 18/20 | 0.85 |
| ▸ | EPHA2 | P29317 | 18/20 | 0.85 |
| ▸ | KDR | P35968 | 16/20 | 0.85 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.85 |
| ▸ | EGFR | P00533 | 2/20 | 0.75 |
| ▸ | FLT1 | P17948 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1224588 | 0.92 | EPHB4 (1.00) | EPHB4EPHA2KDRERBB2EGFR | |
| SCHEMBL907101 | 0.90 | EPHB4 (1.00) | EPHB4EPHA2KDRERBB2EGFR | |
| SCHEMBL1225451 | 0.90 | EPHB4 (1.00) | EPHB4EPHA2KDRERBB2EGFR | |
| SCHEMBL906985 | 0.88 | EPHB4 (1.00) | EPHB4EPHA2KDRERBB2EGFR | |
| SCHEMBL907009 | 0.87 | EPHB4 (1.00) | EPHB4EPHA2KDRERBB2EGFR | |
| SCHEMBL907107 | 0.86 | EPHA2 (0.77) | EPHB4EPHA2KDRERBB2EGFR | |
| SCHEMBL1224404 | 0.86 | EPHB4 (0.87) | EPHB4EPHA2KDRERBB2EGFR | |
| SCHEMBL907250 | 0.86 | EPHB4 (1.00) | EPHB4EPHA2KDRERBB2EGFR | |
| SCHEMBL906917 | 0.86 | EPHB4 (0.88) | EPHB4EPHA2KDRERBB2EGFR | |
| SCHEMBL907004 | 0.85 | EPHB4 (1.00) | EPHB4EPHA2KDRERBB2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2277867-A2 | Compounds, pharmaceutical compositions thereof and their use in treating cancer | Symphony Evolution, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |