Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 11/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8811677 | 1.00 | DHODH (0.55) | DHODHALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL5914909 | 0.80 | DHODH (0.71) | DHODHALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL5914908 | 0.80 | DHODH (0.71) | DHODHALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL445461 | 0.78 | SMN1; SMN2 (0.61) | ALDH1A1MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6143237 | 0.76 | SMN1; SMN2 (0.63) | ALDH1A1MEN1KMT2AGAALMNA | |
| SCHEMBL5914905 | 0.74 | MEN1 (0.70) | DHODHALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL5914893 | 0.74 | DHODH (0.58) | DHODHALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL5914906 | 0.74 | MEN1 (0.70) | DHODHALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL5914892 | 0.74 | DHODH (0.58) | DHODHALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL1721544 | 0.74 | SMN1; SMN2 (0.65) | ALDH1A1MEN1KMT2ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5532259-A | ANTITUMOR | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-07-02 | — | — | US | disclosed |
| US-5494911-A | TREATING LEUKEMIA, SARCOMA, CARCINOMA, LYMPHOMA, SKIN CANCER | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-02-27 | — | — | US | disclosed |