Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9234314 | 0.98 | TDP1 (0.44) | TDP1TAS1R3TAS1R1TAS1R2TSHR | |
| SCHEMBL17034690 | 0.74 | TDP1 (0.52) | TDP1TAS1R3TAS1R1TAS1R2TSHR | |
| Hydrochloric Acid SCHEMBL11734144 | 0.72 | TDP1 (0.41) | TDP1TAS1R3TAS1R1TAS1R2TSHR | |
| SCHEMBL1644167 | 0.71 | PARP1 (0.51) | TDP1TAS1R3TAS1R1TAS1R2TSHR | |
| SCHEMBL30692356 | 0.71 | PARP1 (0.51) | TDP1TAS1R3TAS1R1TAS1R2TSHR | |
| SCHEMBL8329051 | 0.67 | TDP1 (0.46) | TDP1TAS1R3TAS1R1TAS1R2TSHR | |
| Bromide SCHEMBL11733192 | 0.67 | SMN1; SMN2 (0.37) | TDP1TAS1R3TAS1R1TAS1R2TSHR | |
| SCHEMBL28393356 | 0.67 | TDP1 (0.39) | TDP1TAS1R3TAS1R1TAS1R2TSHR | |
| SCHEMBL16284295 | 0.66 | HTR2A (0.44) | TDP1TSHRSMN1; SMN2HSD17B10GAA | |
| SCHEMBL1715556 | 0.66 | GAA (0.42) | TDP1TSHRSMN1; SMN2GAAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5529725-A | PHOTOCHROMIC COMPOUND USED IN LENSES | ESSILOR INTERNATIONAL (FR) | 1996-06-25 | — | — | US | disclosed |