Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27892111 | 0.88 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2NPSR1CYP1A2 | |
| SCHEMBL7945968 | 0.87 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2NPSR1CYP1A2 | |
| SCHEMBL31592087 | 0.87 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2NPSR1CYP1A2 | |
| SCHEMBL7945846 | 0.86 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2NPSR1CYP1A2 | |
| SCHEMBL7959692 | 0.85 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2NPSR1CYP1A2 | |
| SCHEMBL27909128 | 0.85 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2NPSR1CYP1A2 | |
| SCHEMBL12659371 | 0.85 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2NPSR1CYP1A2 | |
| SCHEMBL21852785 | 0.83 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2NPSR1CYP1A2 | |
| SCHEMBL7959722 | 0.82 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2NPSR1CYP1A2 | |
| SCHEMBL7327512 | 0.82 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2NPSR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559143-A | Serotonin 5HT1A agonistic method | MERRELL PHARMACEUTICALS INC. (US) | 1996-09-24 | — | — | US | disclosed |
| US-5387604-A | 1,4 benzodioxin derivatives and their use as serotonin 5HT1A agonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-02-07 | — | — | US | disclosed |
| US-5189179-A | SEROTONIN 5HT1A AGONISTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-02-23 | — | — | US | disclosed |
| EP-0478954-A1 | Serotonin 5HT1A and 5HT1D antagonists | MERRELL PHARMACEUTICALS INC. (US) | 1992-04-08 | — | — | EP | disclosed |
| CN-1059717-A | The serotonin stimulant | MERRELL DOW PHARMA (US) | 1992-03-25 | — | — | CN | disclosed |