Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.53 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 3/20 | 0.49 |
| ▸ | DRD4 | P21917 | 3/20 | 0.49 |
| ▸ | DRD3 | P35462 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25004994 | 0.89 | HRH1 (0.47) | HRH1CARM1PRMT6DRD2DRD4 | |
| SCHEMBL29856 | 0.80 | HRH1 (0.71) | HRH1CARM1PRMT6DRD2DRD4 | |
| SCHEMBL13757100 | 0.80 | HRH1 (0.55) | HRH1CARM1PRMT6DRD2DRD4 | |
| SCHEMBL22878199 | 0.80 | HRH1 (0.55) | HRH1CARM1PRMT6DRD2DRD4 | |
| SCHEMBL3436987 | 0.80 | SMN1; SMN2 (0.71) | HRH1CARM1PRMT6DRD3SMN1; SMN2 | |
| SCHEMBL5541350 | 0.80 | HRH1 (0.55) | HRH1CARM1PRMT6DRD2DRD4 | |
| Ammonia Solution, Strong SCHEMBL8078606 | 0.78 | HRH1 (0.68) | HRH1CARM1PRMT6DRD2DRD4 | |
| SCHEMBL9081468 | 0.78 | PBRM1 (0.45) | HRH1CARM1PRMT6SLC6A2SLC6A3 | |
| SCHEMBL12099373 | 0.77 | HRH1 (0.52) | HRH1CARM1PRMT6DRD2DRD4 | |
| SCHEMBL1307063 | 0.77 | CARM1 (0.66) | HRH1CARM1PRMT6DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015177326-A1 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS WHICH ARE JAK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-11-26 | — | — | WO | disclosed |
| US-5578582-A | Methods of treating ischemia with C2, N6 -disubstituted adenosine derivatives | NOVO NORDISK A/S (DK) | 1996-11-26 | — | — | US | disclosed |
| US-5432164-A | Anticonvulsants | NOVO NORDISK A/S (DK) | 1995-07-11 | — | — | US | disclosed |
| EP-0609375-A1 | NOVEL 2,6-DISUBSTITUTED PURINE DERIVATIVES | NOVO NORDISK A/S (DK) | 1994-08-10 | — | — | EP | disclosed |
| WO-1993008206-A1 | NOVEL 2,6-DISUBSTITUTED PURINE DERIVATIVES | NOVO NORDISK A/S (DK) | 1993-04-29 | — | — | WO | disclosed |