Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12534300 | 0.98 | KMT2A (0.50) | KMT2AHSP90AA1POLBALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5848674 | 0.96 | HSP90AA1 (0.50) | KMT2AHSP90AA1POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL19037381 | 0.79 | KMT2A (0.48) | KMT2AHSP90AA1POLBALDH1A1SMN1; SMN2 | |
| Bromide SCHEMBL344154 | 0.79 | KMT2A (0.50) | KMT2AHSP90AA1ALDH1A1KDM4EMEN1 | |
| Bromide SCHEMBL18549649 | 0.78 | KMT2A (0.58) | KMT2AHSP90AA1POLBALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL19031290 | 0.77 | KMT2A (0.47) | KMT2AHSP90AA1POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL21665861 | 0.77 | KMT2A (0.47) | KMT2AHSP90AA1POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL4232151 | 0.77 | KMT2A (0.47) | KMT2AHSP90AA1POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL8971406 | 0.77 | TSHR (0.48) | KMT2AHSP90AA1ALDH1A1KDM4EHTT | |
| Bromide SCHEMBL344334 | 0.76 | HSP90AA1 (0.49) | KMT2AHSP90AA1ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0356898-B1 | Silver halide photographic materials containing aryl hydrazides | DU PONT DEUTSCHLAND (DE) | 1996-11-27 | — | — | EP | disclosed |
| US-5130480-A | In silver halide elements; images with ultrahigh contrast; reprography, photo typesetting, photomasks | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-07-14 | — | — | US | disclosed |
| US-5013844-A | Photographic emulsions, high contrast | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-05-07 | — | — | US | disclosed |
| US-4937160-A | High contrast | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-06-26 | — | — | US | disclosed |
| EP-0356898-A2 | Silver halide photographic materials containing aryl hydrazides | DU PONT DE NEMOURS (DEUTSCHLAND) GMBH (DE) | 1990-03-07 | — | — | EP | disclosed |