SCHEMBL9080404

SCHEMBL9080404

Cc1nc2c(NC(=O)c3c(Cl)cccc3Cl)cccn2c1Cl

nearest known ligand 0.60

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.48
MEN1 O00255 3/20 0.48
HTT P42858 2/20 0.48
CRHBP P24387 1/20 0.48
CRHR2 Q13324 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
RAB9A P51151 1/20 0.44
TYK2 P29597 3/20 0.43
HPGD P15428 2/20 0.43
JAK2 O60674 2/20 0.43
JAK1 P23458 2/20 0.43
CYP3A4 P08684 1/20 0.43
MAPT P10636 1/20 0.43
ALDH1A1 P00352 2/20 0.42
POLB P06746 1/20 0.41
EPHB3 P54753 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9081354 0.90 KMT2A (0.48) KMT2AMEN1HTTCRHBPCRHR2
Hydrochloric Acid SCHEMBL9081789 0.89 KMT2A (0.47) KMT2AMEN1HTTCRHBPCRHR2
SCHEMBL9082171 0.88 KMT2A (0.46) KMT2AMEN1HTTCRHBPCRHR2
SCHEMBL9278391 0.88 KMT2A (0.46) KMT2AMEN1HTTCRHBPCRHR2
SCHEMBL9080957 0.86 KMT2A (0.46) KMT2AMEN1HTTCRHBPCRHR2
SCHEMBL9230500 0.86 EPHB3 (0.46) KMT2AMEN1HTTCRHBPCRHR2
SCHEMBL9081462 0.86 KMT2A (0.48) KMT2AMEN1HTTCRHBPCRHR2
SCHEMBL9080393 0.84 KMT2A (0.44) KMT2AMEN1HTTCRHBPCRHR2
SCHEMBL9080517 0.84 KMT2A (0.49) KMT2AMEN1HTTCRHBPCRHR2
Hydrochloric Acid SCHEMBL9081193 0.84 KMT2A (0.44) KMT2AMEN1HTTCRHBPCRHR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1996034866-A1 IMIDAZO 1,2-A PYRIDINE AND IMIDAZO 1,2-A PYRIDEZINE DERIVATIVES AND THEIR USE AS BONE RESORPTION INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-11-07 WO disclosed