Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | HTR2C | P28335 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | THPO | P40225 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9082436 | 0.89 | HTR2B (0.60) | HTR2BMEN1TP53CYP1A2CYP3A4 | |
| Iodide SCHEMBL9081357 | 0.86 | MAPT (0.56) | HTR2BMEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL9081676 | 0.86 | MAPT (0.58) | HTR2BMEN1TP53CYP1A2CYP3A4 | |
| Iodide SCHEMBL9081498 | 0.84 | MAPT (0.60) | HTR2BMEN1TP53CYP1A2CYP3A4 | |
| Iodide SCHEMBL9081392 | 0.80 | HTR2B (0.57) | HTR2BMEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL1148605 | 0.80 | HTR2B (0.62) | HTR2BMEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL13808316 | 0.80 | HTR2B (0.58) | HTR2BMEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL29757934 | 0.80 | HTR2B (0.58) | HTR2BMEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL9081502 | 0.80 | HTR2B (0.59) | HTR2BMEN1TP53CYP1A2CYP3A4 | |
| Iodide SCHEMBL9081856 | 0.79 | HTR2C (0.51) | HTR2BMEN1TP53CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996039382-A1 | UREA DERIVATIVES AS 5-HT ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-12-12 | — | — | WO | disclosed |