Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 13/20 | 0.54 |
| ▸ | CTSB | P07858 | 4/20 | 0.54 |
| ▸ | CTSL | P07711 | 4/20 | 0.54 |
| ▸ | CTSK | P43235 | 2/20 | 0.54 |
| ▸ | CAPN9 | O14815 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CTSH | P09668 | 1/20 | 0.54 |
| ▸ | CTSS | P25774 | 1/20 | 0.54 |
| ▸ | CTSC | P53634 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | CTSG | P08311 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9089926 | 0.85 | CAPN1 (0.56) | CAPN1CTSBCTSLCTSKCAPN9 | |
| SCHEMBL11067480 | 0.82 | CAPN1 (0.74) | CAPN1CTSBCTSLCTSKCAPN9 | |
| SCHEMBL11188762 | 0.81 | CAPN1 (0.72) | CAPN1CTSBCTSLCTSKCAPN9 | |
| SCHEMBL11184932 | 0.81 | CAPN1 (0.72) | CAPN1CTSBCTSLCTSKCAPN9 | |
| SCHEMBL9090677 | 0.78 | CHRNA1 (0.58) | CAPN1CTSBCTSLCTSKCAPN9 | |
| SCHEMBL9091432 | 0.78 | CHRNA1 (0.58) | CAPN1CTSBCTSLCTSKCAPN9 | |
| SCHEMBL240780 | 0.78 | CHRNA1 (0.58) | CAPN1CTSBCTSLCTSKCAPN9 | |
| SCHEMBL7208901 | 0.77 | CHRND (0.60) | — | |
| SCHEMBL9089141 | 0.77 | CHRND (0.61) | — | |
| SCHEMBL30643189 | 0.76 | CAPN1 (0.69) | CAPN1CTSBCTSLCTSKCAPN9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5556853-A | THIOL PROTEASE INHIBITORS, TREATMENT OF OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-17 | — | — | US | disclosed |
| EP-0655447-A1 | Epoxysuccinic acid derivatives | Takeda Chemical Industries, Ltd. (JP) | 1995-05-31 | — | — | EP | disclosed |