Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.59 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.58 |
| ▸ | GPR84 | Q9NQS5 | 9/20 | 0.56 |
| ▸ | PPARG | P37231 | 7/20 | 0.56 |
| ▸ | PPARD | Q03181 | 7/20 | 0.56 |
| ▸ | PPARA | Q07869 | 7/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.56 |
| ▸ | TSHR | P16473 | 4/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | TLR2 | O60603 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | FABP4 | P15090 | 2/20 | 0.56 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.56 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ESR1 | P03372 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | PDE4A | P27815 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butyric Acid SCHEMBL4624196 | 0.93 | FFAR4 (0.57) | FFAR4FFAR1AKR1B1GPR84PPARG | |
| Valeric Acid SCHEMBL7775558 | 0.93 | AKR1B1 (0.62) | FFAR4FFAR1AKR1B1GPR84PPARG | |
| Heptanoate SCHEMBL3912175 | 0.91 | FFAR4 (0.71) | FFAR4FFAR1AKR1B1GPR84PPARG | |
| Myristic Acid SCHEMBL7030694 | 0.91 | FFAR4 (0.71) | FFAR4FFAR1AKR1B1GPR84PPARG | |
| Nonanoate SCHEMBL9821999 | 0.91 | FFAR4 (0.71) | FFAR4FFAR1AKR1B1GPR84PPARG | |
| Behenic Acid SCHEMBL8407766 | 0.91 | FFAR4 (0.71) | FFAR4FFAR1AKR1B1GPR84PPARG | |
| Palmitic Acid SCHEMBL3253364 | 0.91 | FFAR4 (0.71) | FFAR4FFAR1AKR1B1GPR84PPARG | |
| Sebacic Acid SCHEMBL9091254 | 0.91 | FFAR4 (0.71) | FFAR4FFAR1AKR1B1GPR84PPARG | |
| Butyric Acid SCHEMBL9192458 | 0.91 | FFAR4 (0.60) | FFAR4FFAR1AKR1B1GPR84PPARG | |
| Palmitic Acid SCHEMBL7024981 | 0.91 | FFAR4 (0.71) | FFAR4FFAR1AKR1B1GPR84PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5574163-A | TRANSESTERIFICATION | CIBA-GEIGY CORPORATION (US) | 1996-11-12 | — | — | US | disclosed |