Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | F12 | P00748 | 1/20 | 0.34 |
| ▸ | GPR6 | P46095 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2249696 | 0.69 | PDGFRB (0.47) | NPC1RAB9APIK3R1PIK3CAPIK3CD | |
| SCHEMBL4990795 | 0.63 | NPC1 (0.39) | NPC1RAB9AF12CNR2 | |
| SCHEMBL23921753 | 0.63 | NPC1 (0.38) | NPC1RAB9AF12PDE10ACNR2 | |
| SCHEMBL22702917 | 0.62 | F12 (0.46) | F12 | |
| SCHEMBL22492312 | 0.62 | F12 (0.39) | NPC1RAB9AF12 | |
| SCHEMBL4982872 | 0.61 | NPC1 (0.39) | NPC1RAB9AF12 | |
| SCHEMBL19493556 | 0.60 | ESR1 (0.44) | CYP2C19NPC1RAB9AF12CNR2 | |
| SCHEMBL12680946 | 0.60 | NPC1 (0.60) | NPC1RAB9APDE10ACNR2 | |
| SCHEMBL2915641 | 0.59 | F12 (0.38) | NPC1RAB9AF12 | |
| SCHEMBL23921754 | 0.59 | KCNK3 (0.35) | NPC1RAB9AF12GPR6PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459197-A1 | COMPOUNDS FOR THE REDUCTION OF -AMYLOID PRODUCTION | Bristol-Myers Squibb Company (US) | 2012-06-06 | — | — | EP | claimed |