Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9103408 | 0.93 | PTPN1 (0.48) | PTPN1FFAR1S1PR1S1PR3NPC1 | |
| Beta-Alanine SCHEMBL15377677 | 0.91 | PTPN1 (0.46) | PTPN1FFAR1S1PR1S1PR3S1PR5 | |
| SCHEMBL9103709 | 0.86 | S1PR1 (0.55) | PTPN1FFAR1S1PR1S1PR3S1PR4 | |
| SCHEMBL9101175 | 0.83 | PTPN1 (0.45) | PTPN1FFAR1S1PR1S1PR3TP53 | |
| SCHEMBL15378312 | 0.82 | PTPN1 (0.48) | PTPN1S1PR1S1PR3NPC1RAB9A | |
| SCHEMBL27942821 | 0.82 | PTPN1 (0.47) | PTPN1S1PR1S1PR3RAB9ATP53 | |
| SCHEMBL9913930 | 0.80 | PTPN1 (0.44) | PTPN1S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL9102874 | 0.80 | S1PR1 (0.50) | S1PR1S1PR3S1PR5 | |
| SCHEMBL9104995 | 0.80 | PTPN1 (0.46) | PTPN1 | |
| SCHEMBL9104113 | 0.79 | PTPN1 (0.47) | PTPN1S1PR1S1PR3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2646021-B1 | OXADIAZOLE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P)RECEPTOR MODULATORS | ALLERGAN INC (US) | 2014-11-05 | — | — | EP | disclosed |
| US-8846728-B2 | Oxadiazole derivatives as sphingosine 1-phosphate (S1P) receptor modulators | ALLERGAN, INC. (US) | 2014-09-30 | — | — | US | disclosed |
| US-20130303577-A1 | OXADIAZOLE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS | ALLERGAN, INC. | 2013-11-14 | — | — | US | disclosed |
| US-8497254-B2 | Oxadiazole derivatives as sphingosine 1-phosphate (S1P) receptor modulators | ALLERGAN, INC. (US) | 2013-07-30 | — | — | US | disclosed |
| US-20120142639-A1 | OXADIAZOLE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142639-A1 | OXADIAZOLE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS | S1PR3, S1PR1, S1PR2 | PTPN1 1043/4885FFAR1 28/4885S1PR1 2/4885 |
| US-20130303577-A1 | OXADIAZOLE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS | S1PR3, S1PR1, S1PR2 | PTPN1 1043/4885FFAR1 28/4885S1PR1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.