Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 20/20 | 0.76 |
| ▸ | JAK2 | O60674 | 3/20 | 0.76 |
| ▸ | LCK | P06239 | 3/20 | 0.76 |
| ▸ | JAK1 | P23458 | 1/20 | 0.67 |
| ▸ | TYK2 | P29597 | 1/20 | 0.67 |
| ▸ | STAT3 | P40763 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20135286 | 0.94 | JAK3 (0.75) | JAK3JAK2LCKJAK1TYK2 | |
| SCHEMBL12909912 | 0.94 | JAK3 (0.75) | JAK3JAK2LCKJAK1TYK2 | |
| SCHEMBL19011863 | 0.92 | JAK3 (0.76) | JAK3JAK2LCKJAK1TYK2 | |
| SCHEMBL10205629 | 0.90 | JAK3 (0.81) | JAK3JAK2LCKJAK1TYK2 | |
| SCHEMBL19011896 | 0.88 | JAK3 (0.78) | JAK3JAK2LCKJAK1TYK2 | |
| SCHEMBL15854608 | 0.87 | JAK3 (0.72) | JAK3JAK2LCKJAK1TYK2 | |
| SCHEMBL1948756 | 0.86 | JAK3 (1.00) | JAK3JAK2LCKJAK1TYK2 | |
| SCHEMBL12546704 | 0.86 | JAK3 (1.00) | JAK3JAK2LCKJAK1TYK2 | |
| SCHEMBL18365714 | 0.86 | JAK3 (1.00) | JAK3JAK2LCKJAK1TYK2 | |
| SCHEMBL12547004 | 0.86 | JAK3 (1.00) | JAK3JAK2LCKJAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858349-A1 | NITROGEN-CONTAINING SPIRO-RING COMPOUND AND MEDICINAL USE OF SAME | Japan Tobacco Inc. (JP) | 2021-08-04 | — | — | EP | disclosed |
| EP-3181570-A1 | NITROGEN-CONTAINING SPIRO-RING COMPOUND AND MEDICINAL USE OF SAME | Japan Tobacco Inc. (JP) | 2017-06-21 | — | — | EP | disclosed |
| EP-2460806-B1 | NITROGEN-CONTAINING SPIRO-RING COMPOUND AND MEDICINAL USE OF SAME | JAPAN TOBACCO INC (JP) | 2017-01-04 | — | — | EP | disclosed |
| EP-2460806-A1 | NITROGEN-CONTAINING SPIRO-RING COMPOUND AND MEDICINAL USE OF SAME | Japan Tobacco, Inc. (JP) | 2012-06-06 | — | — | EP | disclosed |