Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA4 | P22748 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2014666 | 0.95 | CA1 (0.56) | CA1CA2CA4CA9ALDH1A1 | |
| SCHEMBL8229902 | 0.95 | CA1 (0.56) | CA1CA2CA4CA9ALDH1A1 | |
| SCHEMBL4708831 | 0.95 | CA1 (0.56) | CA1CA2CA4CA9ALDH1A1 | |
| Piperazine SCHEMBL9028956 | 0.90 | CA1 (0.52) | CA1CA2CA4CA9ALDH1A1 | |
| Piperazine SCHEMBL9028960 | 0.90 | CA1 (0.52) | CA1CA2CA4CA9ALDH1A1 | |
| SCHEMBL19878826 | 0.89 | CA1 (0.50) | CA1CA2CA4CA9ALDH1A1 | |
| SCHEMBL19878828 | 0.89 | CA1 (0.50) | CA1CA2CA4CA9ALDH1A1 | |
| SCHEMBL8575175 | 0.89 | CA1 (0.49) | CA1CA2CA4CA9ALDH1A1 | |
| SCHEMBL13705078 | 0.89 | CA1 (0.49) | CA1CA2CA4CA9ALDH1A1 | |
| SCHEMBL15020095 | 0.86 | NR1H2 (0.47) | CA1CA2CA4CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459557-B1 | CYCLIC (AZA)INDOLIZINECARBOXAMIDES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | SANOFI SA (FR) | 2013-09-18 | — | — | EP | disclosed |
| EP-2459557-A1 | CYCLIC (AZA)INDOLIZINECARBOXAMIDES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2012-06-06 | — | — | EP | disclosed |