Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.79 |
| ▸ | PIK3CD | O00329 | 19/20 | 0.79 |
| ▸ | PIK3R1 | P27986 | 19/20 | 0.79 |
| ▸ | PIK3CB | P42338 | 13/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL910057 | 0.95 | PIK3CA (0.77) | PIK3CAPIK3CDPIK3R1PIK3CB | |
| SCHEMBL6523951 | 0.95 | PIK3CA (0.77) | PIK3CAPIK3CDPIK3R1PIK3CB | |
| SCHEMBL909204 | 0.91 | PIK3CA (0.75) | PIK3CAPIK3CDPIK3R1PIK3CB | |
| SCHEMBL6525372 | 0.91 | PIK3CA (0.78) | PIK3CAPIK3CDPIK3R1PIK3CB | |
| SCHEMBL6526256 | 0.91 | PIK3CA (0.78) | PIK3CAPIK3CDPIK3R1PIK3CB | |
| SCHEMBL2815848 | 0.90 | PIK3CA (0.74) | PIK3CAPIK3CDPIK3R1PIK3CB | |
| SCHEMBL908601 | 0.90 | PIK3CA (0.65) | PIK3CAPIK3CDPIK3R1PIK3CB | |
| SCHEMBL12847245 | 0.89 | PIK3CA (0.74) | PIK3CAPIK3CDPIK3R1PIK3CB | |
| SCHEMBL12846971 | 0.89 | PIK3CA (0.74) | PIK3CAPIK3CDPIK3R1PIK3CB | |
| SCHEMBL477325 | 0.88 | PIK3CD (1.00) | PIK3CAPIK3CDPIK3R1PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276750-A2 | SUBSTITUTED PYRIMIDINES AND TRIAZINES AND THEIR USE IN CANCER THERAPY | Auckland Uniservices Limited (NZ) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009120094-A2 | SUBSTITUTED PYRIMIDINES AND TRIAZINES AND THEIR USE IN CANCER THERAPY | AUCKLAND UNISERVICES LIMITED (NZ) | 2009-10-01 | — | — | WO | disclosed |