Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 8/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.32 |
| ▸ | FKBP1B | P68106 | 1/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL910828 | 0.99 | TOP2A (0.46) | TOP2APIM1MTORFKBP1AFKBP1B | |
| SCHEMBL910186 | 0.95 | TOP2A (0.43) | TOP2APIM1MTORFKBP1AFKBP1B | |
| SCHEMBL3725589 | 0.95 | TOP2A (0.43) | TOP2APIM1MTORFKBP1AFKBP1B | |
| Hydrochloric Acid SCHEMBL910182 | 0.94 | TOP2A (0.42) | TOP2APIM1MTORFKBP1AFKBP1B | |
| Hydrochloric Acid SCHEMBL910447 | 0.94 | TOP2A (0.42) | TOP2APIM1MTORFKBP1AFKBP1B | |
| Trifluoroacetic Acid SCHEMBL909865 | 0.91 | TOP2A (0.41) | TOP2AMTORFKBP1AFKBP1BPRKDC | |
| SCHEMBL335505 | 0.91 | TOP2A (0.55) | TOP2APIM1MTORFKBP1AFKBP1B | |
| SCHEMBL335558 | 0.91 | TOP2A (0.55) | TOP2APIM1MTORFKBP1AFKBP1B | |
| SCHEMBL336118 | 0.91 | TOP2A (0.55) | TOP2APIM1MTORFKBP1AFKBP1B | |
| Hydrochloric Acid SCHEMBL3328648 | 0.90 | TOP2A (0.54) | TOP2APIM1MTORFKBP1AFKBP1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009394-A1 | TRICYCLIC NITROGEN COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2011-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009394-A1 | TRICYCLIC NITROGEN COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS | NRDC, NCL, NPM1 | TOP2A 96/4885PIM1 3360/4885MTOR 179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.