Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.38 |
| ▸ | ITGAL | P20701 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9105161 | 1.00 | SMN1; SMN2 (0.58) | SMN1; SMN2KDM4ECYP2C19HSD17B10KMT2A | |
| SCHEMBL28087269 | 0.95 | SMN1; SMN2 (0.53) | SMN1; SMN2KDM4ECYP2C19HSD17B10KMT2A | |
| SCHEMBL15129357 | 0.85 | ELANE (0.47) | SMN1; SMN2KDM4ECYP2C19OGFRL1 | |
| SCHEMBL15129611 | 0.82 | MAPT (0.51) | SMN1; SMN2KDM4EHSD17B10KMT2AMAPT | |
| SCHEMBL21853236 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4EHSD17B10KMT2AMAPT | |
| SCHEMBL21853250 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4EHSD17B10KMT2AMAPT | |
| SCHEMBL28071008 | 0.80 | KDM4E (0.41) | SMN1; SMN2KDM4ECYP2C19HSD17B10KMT2A | |
| SCHEMBL29140141 | 0.80 | SMN1; SMN2 (0.43) | SMN1; SMN2KDM4ECYP2C19HSD17B10KMT2A | |
| SCHEMBL8926206 | 0.79 | SMN1; SMN2 (0.51) | SMN1; SMN2KDM4ECYP2C19HSD17B10KMT2A | |
| SCHEMBL29221025 | 0.77 | SMN1; SMN2 (0.67) | SMN1; SMN2HSD17B10KMT2AALDH1A1OGFRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8629157-B2 | Pyrrolidine compounds which modulate the CB2 receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-14 | — | — | US | disclosed |
| US-20120142677-A1 | Pyrrolidine Compounds Which Modulate The CB2 Receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142677-A1 | Pyrrolidine Compounds Which Modulate The CB2 Receptor | CNR2, CNR1, OPRL1 | SMN1; SMN2 4659/4885KDM4E 2527/4885CYP2C19 1646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.