Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 15/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL910512 | 1.00 | TOP2A (0.44) | TOP2ASLC2A1KCNH2 | |
| Hydrochloric Acid SCHEMBL910023 | 0.99 | SLC2A1 (0.44) | TOP2ASLC2A1KCNH2 | |
| Hydrochloric Acid SCHEMBL910102 | 0.99 | SLC2A1 (0.44) | TOP2ASLC2A1KCNH2 | |
| SCHEMBL909985 | 0.90 | KCNH2 (0.49) | TOP2ASLC2A1KCNH2 | |
| Hydrochloric Acid SCHEMBL910352 | 0.89 | KCNH2 (0.49) | TOP2ASLC2A1KCNH2 | |
| SCHEMBL910652 | 0.87 | TOP2A (0.46) | TOP2ASLC2A1KCNH2 | |
| SCHEMBL3725113 | 0.87 | TOP2A (0.59) | TOP2AKCNH2 | |
| SCHEMBL910716 | 0.87 | TOP2A (0.59) | TOP2AKCNH2 | |
| Hydrochloric Acid SCHEMBL909916 | 0.86 | TOP2A (0.45) | TOP2ASLC2A1KCNH2 | |
| Hydrochloric Acid SCHEMBL909842 | 0.86 | TOP2A (0.58) | TOP2ASLC2A1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009394-A1 | TRICYCLIC NITROGEN COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2011-01-13 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009394-A1 | TRICYCLIC NITROGEN COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS | NRDC, NCL, NPM1 | TOP2A 96/4885SLC2A1 3904/4885KCNH2 3726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.