Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NT5E | P21589 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MGAM | O43451 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | SI | P14410 | 2/20 | 0.47 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.47 |
| ▸ | PRKCG | P05129 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9106700 | 1.00 | GPBAR1 (0.48) | GPBAR1LMNANT5ESMN1; SMN2MGAM | |
| SCHEMBL16995400 | 1.00 | GPBAR1 (0.48) | GPBAR1LMNANT5ESMN1; SMN2MGAM | |
| SCHEMBL9106538 | 1.00 | GPBAR1 (0.48) | GPBAR1LMNANT5ESMN1; SMN2MGAM | |
| SCHEMBL18124320 | 1.00 | GPBAR1 (0.48) | GPBAR1LMNANT5ESMN1; SMN2MGAM | |
| SCHEMBL9888494 | 0.92 | GPBAR1 (0.50) | GPBAR1LMNANT5ESMN1; SMN2MGAM | |
| SCHEMBL22779964 | 0.89 | MGAM (0.37) | MGAMGAASIMGAM2 | |
| SCHEMBL9889521 | 0.89 | GPBAR1 (0.49) | GPBAR1LMNANT5ESMN1; SMN2PRKCG | |
| SCHEMBL9888542 | 0.89 | GPBAR1 (0.53) | GPBAR1LMNANT5ESMN1; SMN2PRKCG | |
| SCHEMBL9105293 | 0.89 | GPBAR1 (0.53) | GPBAR1LMNANT5ESMN1; SMN2PRKCG | |
| SCHEMBL9108591 | 0.88 | NR1H4 (0.45) | GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576585-B1 | MODIFIED C-3 BETULINIC ACID DERIVATIVES AS HIV MATURATION INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-10-12 | — | — | EP | disclosed |
| US-9249180-B2 | C-3 alkyl and alkenyl modified betulinic acid derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-02-02 | — | — | US | disclosed |
| US-20140243298-A1 | C-3 ALKYL AND ALKENYL MODIFIED BETULINIC ACID DERIVATIVES | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2014-08-28 | — | — | US | disclosed |
| US-8754068-B2 | Modified C-3 betulinic acid derivatives as HIV maturation inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-06-17 | — | — | US | disclosed |
| US-20120142707-A1 | MODIFIED C-3 BETULINIC ACID DERIVATIVES AS HIV MATURATION INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140243298-A1 | C-3 ALKYL AND ALKENYL MODIFIED BETULINIC ACID DERIVATIVES | BET1, TMPO, PGGT1B | GPBAR1 896/4885LMNA 1045/4885NT5E 2800/4885 |
| US-20120142707-A1 | MODIFIED C-3 BETULINIC ACID DERIVATIVES AS HIV MATURATION INHIBITORS | BET1, BIRC3, CYTH3 | GPBAR1 2452/4885LMNA 1373/4885NT5E 2427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.