Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 12/20 | 0.69 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.69 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.69 |
| ▸ | HRH1 | P35367 | 2/20 | 0.69 |
| ▸ | ESR1 | P03372 | 1/20 | 0.69 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.69 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.69 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.69 |
| ▸ | HRH2 | P25021 | 1/20 | 0.69 |
| ▸ | HTR2A | P28223 | 1/20 | 0.69 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.69 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.69 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.69 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.69 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.69 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9109556 | 1.00 | CHRM3 (0.69) | CHRM3CHRM2CHRM1LMNAMAPT | |
| Cadaverine Tartrate SCHEMBL9104855 | 0.92 | CHRM3 (0.73) | CHRM3CHRM2CHRM1LMNAMAPT | |
| Cadaverine Tartrate SCHEMBL9104827 | 0.92 | CHRM3 (0.73) | CHRM3CHRM2CHRM1LMNAMAPT | |
| SCHEMBL820438 | 0.83 | CHRM3 (0.74) | CHRM3CHRM2CHRM1LMNAMAPT | |
| SCHEMBL4663933 | 0.83 | CHRM3 (0.74) | CHRM3CHRM2CHRM1LMNAMAPT | |
| SCHEMBL2473562 | 0.83 | CHRM3 (0.78) | CHRM3CHRM2CHRM1LMNAMAPT | |
| SCHEMBL2473559 | 0.83 | CHRM3 (0.78) | CHRM3CHRM2CHRM1LMNAMAPT | |
| Hydrochloric Acid SCHEMBL815785 | 0.82 | CHRM3 (0.72) | CHRM3CHRM2CHRM1LMNAMAPT | |
| Tolterodine SCHEMBL1262757 | 0.82 | CHRM3 (0.95) | CHRM3CHRM2CHRM1LMNAMAPT | |
| Tolterodine SCHEMBL36882 | 0.82 | CHRM3 (1.00) | CHRM3CHRM2CHRM1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044001-B1 | PROCESS FOR PREPARATION OF 3-(2-HYDROXY-5-SUBSTITUTED PHENYL)-N-ALKYL-3-PHENYLPROPYLAMINES | LEK PHARMACEUTICALS (SI) | 2016-11-23 | — | — | EP | disclosed |
| EP-2545024-B1 | PROCESS FOR PREPARATION OF 3-(2-HYDROXY-5-SUBSTITUTED PHENYL)-3-PHENYLPROPYLAMINES, INTERMEDIATES FOR MAKING HYDROXYTOLTERODINE AND FESOTERODINE | LEK PHARMACEUTICALS (SI) | 2016-08-03 | — | — | EP | disclosed |
| US-20130197082-A1 | SHORT SYNTHESIS OF TOLTERODINE, INTERMEDIATES AND METABOLITES | LEK PHARMACEUTICALS D.D. (SI) | 2013-08-01 | — | — | US | disclosed |
| US-8193391-B2 | Process for preparation of 3-(2-hydroxy-5-substituted phenyl)-N-alkyl-3-phenylpropylamines | LEK PHARMACEUTICALS, D.D. (SI) | 2012-06-05 | — | — | US | disclosed |
| EP-2364966-A1 | Process for preparation of 3-(2-hydroxy-5-substituted phenyl)-3-phenylpropylamines, intermediates for making hydroxytolterodine | LEK Pharmaceuticals d.d. (SI) | 2011-09-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130197082-A1 | SHORT SYNTHESIS OF TOLTERODINE, INTERMEDIATES AND METABOLITES | COMT, UGT1A7, PAH | CHRM3 772/4885CHRM2 867/4885CHRM1 1092/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.