Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 6/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 6/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | HSD3B1 | P14060 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | MBOAT4 | Q96T53 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7901229 | 0.85 | SRD5A1 (0.55) | SRD5A1SRD5A2CYP19A1LMNACYP3A4 | |
| SCHEMBL7901226 | 0.85 | SRD5A1 (0.55) | SRD5A1SRD5A2CYP19A1LMNACYP3A4 | |
| SCHEMBL9134039 | 0.77 | SRD5A1 (0.52) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| SCHEMBL9134036 | 0.77 | SRD5A1 (0.52) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| SCHEMBL950330 | 0.76 | SRD5A1 (0.53) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| SCHEMBL950331 | 0.76 | SRD5A1 (0.53) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| SCHEMBL790657 | 0.76 | SRD5A1 (0.53) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| SCHEMBL7978401 | 0.74 | SRD5A1 (0.38) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| SCHEMBL7978400 | 0.74 | SRD5A1 (0.38) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| SCHEMBL9319615 | 0.72 | SRD5A1 (0.37) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0646007-A4 | — | — | 1995-04-26 | — | — | EP | disclosed |
| EP-0646007-A1 | NEW DELTA-17 AND DELTA-20 OLEFINIC AND SATURATED 17-g(b)-SUBSTITUTED-4-AZA-5-g(a)-ANDROSTAN-3-ONES AS 5-g(a)-REDUCTASE INHIBITORS. | MERCK & CO INC (US) | 1995-04-05 | — | — | EP | disclosed |