Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.58 |
| ▸ | KDM1A | O60341 | 5/20 | 0.57 |
| ▸ | CSF1R | P07333 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | FLT1 | P17948 | 2/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | KIF5B | P33176 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8649611 | 0.94 | EGFR (0.52) | EGFRKDM1ACSF1RKDRFLT1 | |
| SCHEMBL8647215 | 0.91 | EGFR (0.56) | EGFRKDM1ACSF1RKDRFLT1 | |
| SCHEMBL8657810 | 0.89 | EGFR (0.58) | EGFRKDM1ACSF1RKDRPDGFRB | |
| SCHEMBL8645752 | 0.88 | EGFR (0.62) | EGFRCSF1RKDRFLT1PDGFRB | |
| SCHEMBL8649000 | 0.88 | EGFR (0.73) | EGFRCSF1RKDRPDGFRBKIT | |
| SCHEMBL8647397 | 0.86 | EGFR (0.57) | EGFRKDM1ACSF1RKDRFLT1 | |
| Hydrochloric Acid SCHEMBL8648503 | 0.86 | KDR (0.48) | EGFRKDM1ACSF1RKDRFLT1 | |
| SCHEMBL8649983 | 0.84 | EGFR (0.64) | EGFRCSF1RKDRPDGFRBKIT | |
| SCHEMBL9115373 | 0.84 | EGFR (0.56) | EGFRCSF1RKDRPDGFRBKIT | |
| SCHEMBL8652546 | 0.84 | EGFR (0.56) | EGFRCSF1RKDRFLT1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995023141-A1 | 4-HETEROCYCLYL-SUBSTITUTED QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS ANTI-CANCER AGENTS | PFIZER INC. (US) | 1995-08-31 | — | — | WO | disclosed |