Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KDM4A | O75164 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ANPEP | P15144 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9115562 | 1.00 | POLB (0.61) | POLBKMT2ACYP2D6CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL8611963 | 0.99 | POLB (0.59) | POLBKMT2ACYP2D6CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL8611957 | 0.99 | POLB (0.59) | POLBKMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10448164 | 0.87 | KDM4E (0.54) | POLBCA2HTTGAA | |
| SCHEMBL12310885 | 0.86 | KMT2A (0.58) | POLBKMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7806369 | 0.86 | KMT2A (0.58) | POLBKMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7806373 | 0.86 | KMT2A (0.58) | POLBKMT2ACYP2D6CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL8615985 | 0.85 | ANPEP (0.59) | POLBANPEP | |
| Hydrochloric Acid SCHEMBL8615979 | 0.85 | ANPEP (0.59) | POLBANPEP | |
| Hydrochloric Acid SCHEMBL8617611 | 0.85 | KMT2A (0.56) | POLBKMT2ACYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664789-A4 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE. | — | 1995-09-06 | — | — | EP | disclosed |
| EP-0664789-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | Merck & Co., Inc. (a New Jersey corp.) (US) | 1995-08-02 | — | — | EP | disclosed |
| WO-1994000419-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1994-01-06 | — | — | WO | disclosed |