SCHEMBL9118450

SCHEMBL9118450

CC(=O)C=Cc1cncc(Br)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GLA P06280 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
IAPP P10997 1/20 0.43
PTGS1 P23219 1/20 0.43
POLB P06746 1/20 0.43
HCAR2 Q8TDS4 1/20 0.43
PADI4 Q9UM07 1/20 0.43
HTT P42858 4/20 0.41
GAA P10253 1/20 0.41
MAPT P10636 3/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
ALDH1A1 P00352 1/20 0.40
HSD17B3 P37058 1/20 0.40
CYP1A1 P04798 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP1B1 Q16678 1/20 0.39
RAB9A P51151 2/20 0.39
KDM4E B2RXH2 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9118435 1.00 GLA (0.44) GLATDP1IAPPPTGS1POLB
SCHEMBL746977 0.84 HCAR2 (0.48) GLATDP1POLBHCAR2PADI4
SCHEMBL746816 0.84 HCAR2 (0.48) GLATDP1POLBHCAR2PADI4
SCHEMBL17157645 0.82 POLB (0.43) POLBHCAR2PADI4HTTGAA
SCHEMBL17157644 0.82 POLB (0.43) POLBHCAR2PADI4HTTGAA
SCHEMBL745343 0.81 KDM4E (0.50) POLBHCAR2PADI4HTTGAA
SCHEMBL745342 0.81 KDM4E (0.50) POLBHCAR2PADI4HTTGAA
SCHEMBL3752783 0.81 AKR1C3 (0.43) POLBHCAR2PADI4HTTMAPT
SCHEMBL3092230 0.81 AKR1C3 (0.43) POLBHCAR2PADI4HTTMAPT
SCHEMBL4172750 0.81 KMT2A (0.44) POLBHCAR2PADI4HTTMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1995028400-A1 NOVEL BENZOFUSED 5-MEMBERED HETEROCYCLIC RINGS FOR THE TREATMENT OF MIGRAINE GLAXO GROUP LIMITED (GB) 1995-10-26 WO disclosed