Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 13/20 | 0.75 |
| ▸ | MEN1 | O00255 | 1/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.75 |
| ▸ | MAPT | P10636 | 1/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.75 |
| ▸ | TSHR | P16473 | 1/20 | 0.75 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.75 |
| ▸ | BLM | P54132 | 1/20 | 0.75 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.75 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.75 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.75 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9118693 | 0.86 | HSP90AA1 (0.81) | HSP90AA1MEN1CYP1A2CYP3A4MAPT | |
| SCHEMBL2820871 | 0.86 | HSP90AA1 (1.00) | HSP90AA1MEN1CYP1A2CYP3A4MAPT | |
| SCHEMBL29598579 | 0.86 | HSP90AA1 (1.00) | HSP90AA1MEN1CYP1A2CYP3A4MAPT | |
| SCHEMBL29630342 | 0.86 | HSP90AA1 (1.00) | HSP90AA1MEN1CYP1A2CYP3A4MAPT | |
| SCHEMBL9119790 | 0.85 | KMT2A (0.54) | HSP90AA1MEN1CYP1A2CYP3A4MAPT | |
| SCHEMBL5438828 | 0.85 | HSP90AA1 (0.70) | HSP90AA1MEN1CYP1A2CYP3A4MAPT | |
| SCHEMBL4139002 | 0.83 | HSP90AA1 (0.75) | HSP90AA1MEN1CYP1A2CYP3A4MAPT | |
| SCHEMBL5430236 | 0.83 | HSP90AA1 (0.75) | HSP90AA1MEN1CYP1A2CYP3A4MAPT | |
| SCHEMBL5440578 | 0.82 | HSP90AA1 (0.74) | HSP90AA1MEN1CYP1A2CYP3A4MAPT | |
| SCHEMBL5436437 | 0.82 | HSP90AA1 (0.70) | HSP90AA1MEN1CYP1A2CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0477819-B1 | Benzimidazole derivatives, their preparation and use | NEUROSEARCH AS (DK) | 1995-03-15 | — | — | EP | disclosed |
| US-5200422-A | Benzimidazole derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1993-04-06 | — | — | US | disclosed |
| EP-0477819-A2 | Benzimidazole derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1992-04-01 | — | — | EP | disclosed |