Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.53 |
| ▸ | PPARA | Q07869 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PTPRC | P08575 | 2/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9121594 | 1.00 | PPARG (0.53) | PPARGPPARACNR2PPARDLTB4R | |
| SCHEMBL9119423 | 1.00 | PPARG (0.53) | PPARGPPARACNR2PPARDLTB4R | |
| SCHEMBL9119193 | 1.00 | PPARG (0.53) | PPARGPPARACNR2PPARDLTB4R | |
| SCHEMBL9121693 | 1.00 | PPARG (0.53) | PPARGPPARACNR2PPARDLTB4R | |
| SCHEMBL8463998 | 0.97 | PPARG (0.48) | PPARGPPARACNR2PPARDPTGES | |
| SCHEMBL9122739 | 0.88 | PPARD (0.44) | PPARGPPARDPTGESALOX5TSHR | |
| SCHEMBL8464381 | 0.87 | PPARG (0.47) | PPARGPPARACNR2PPARDPTGES | |
| SCHEMBL8799678 | 0.85 | PPARG (0.37) | PPARGPPARAPPARDPTGESALOX5 | |
| SCHEMBL8799004 | 0.85 | PPARG (0.38) | PPARGPPARDPTGESALOX5TSHR | |
| SCHEMBL9119381 | 0.83 | CYP4F2 (0.37) | PPARGPPARAPPARDPTGESALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434186-A | Antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1995-07-18 | — | — | US | disclosed |
| EP-0531823-A1 | Bicyclic carboxylic acid derivatives as anti-inflammatory agents | F. HOFFMANN-LA ROCHE AG (CH) | 1993-03-17 | — | — | EP | disclosed |