Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9123206 | 0.96 | NPSR1 (0.59) | NPSR1SMN1; SMN2KMT2AHPGDEPHX1 | |
| SCHEMBL9123923 | 0.94 | NPSR1 (0.62) | NPSR1SMN1; SMN2KMT2AHPGDEPHX1 | |
| SCHEMBL9125198 | 0.94 | NPSR1 (0.62) | NPSR1SMN1; SMN2KMT2AHPGDEPHX1 | |
| SCHEMBL9124383 | 0.92 | NPSR1 (0.48) | NPSR1SMN1; SMN2KMT2AHPGDEPHX1 | |
| SCHEMBL9121153 | 0.85 | NPSR1 (0.51) | NPSR1SMN1; SMN2KMT2AHPGDEPHX1 | |
| SCHEMBL9124374 | 0.81 | NPSR1 (0.56) | NPSR1SMN1; SMN2KMT2AHPGDEPHX1 | |
| SCHEMBL12438989 | 0.81 | NPSR1 (0.59) | NPSR1SMN1; SMN2KMT2AHPGDEPHX1 | |
| SCHEMBL9121154 | 0.80 | NPSR1 (0.59) | NPSR1SMN1; SMN2KMT2AHPGDEPHX1 | |
| SCHEMBL2092325 | 0.80 | NPSR1 (0.58) | NPSR1SMN1; SMN2KMT2AHPGDEPHX1 | |
| SCHEMBL29256270 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1030607-C | Tetracyclic compounds having anti-allergic and anti-asthmatic activities, their prepn. and use | SANKYO CO (JP) | 1996-01-03 | — | — | CN | disclosed |
| US-5476848-A | Antihistamines | SANKYO COMPANY, LIMITED (JP) | 1995-12-19 | — | — | US | disclosed |
| US-5461051-A | Tetracyclic compounds having anti-allergic and anti-asthmatic activities and their use | SANKYO COMPANY, LIMITED (JP) | 1995-10-24 | — | — | US | disclosed |
| US-5362725-A | Antiallergens, antiasthmatic | SANKYO COMPANY, LIMITED (JP) | 1994-11-08 | — | — | US | disclosed |
| EP-0505014-A2 | Novel tetracyclic compounds having anti-allergic and anti-asthmatic activities, their preparation and use | Sankyo Company Limited (JP) | 1992-09-23 | — | — | EP | disclosed |
| CN-1051360-A | Have agaist allergic symptoms and the active new tetracyclic compound of anti-asthma, its preparation and application | SANKYO CO (JP) | 1991-05-15 | — | — | CN | disclosed |
| EP-0421823-A2 | Novel tetracyclic compounds having anti-allergic and anti-asthmatic activities, their preparation and use | Sankyo Company Limited (JP) | 1991-04-10 | — | — | EP | disclosed |