Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 9/20 | 0.52 |
| ▸ | NQO1 | P15559 | 4/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10800468 | 0.94 | TOP2A (0.55) | TOP2ANQO1CYP19A1SMN1; SMN2MEN1 | |
| SCHEMBL10805685 | 0.93 | TOP2A (0.49) | TOP2ANQO1CYP19A1SMN1; SMN2MEN1 | |
| SCHEMBL10805037 | 0.91 | TOP2A (0.50) | TOP2ANQO1CYP19A1SMN1; SMN2MEN1 | |
| SCHEMBL10801676 | 0.90 | TOP2A (0.66) | TOP2ANQO1CYP19A1SMN1; SMN2MEN1 | |
| SCHEMBL10804138 | 0.90 | TOP2A (0.66) | TOP2ANQO1CYP19A1SMN1; SMN2MEN1 | |
| SCHEMBL9127738 | 0.88 | TOP2A (0.50) | TOP2ACYP19A1SMN1; SMN2MEN1USP2 | |
| SCHEMBL10801133 | 0.88 | TOP2A (0.55) | TOP2ANQO1CYP19A1SMN1; SMN2MEN1 | |
| SCHEMBL10800278 | 0.87 | TOP2A (0.48) | TOP2ANQO1CYP19A1SMN1; SMN2MEN1 | |
| SCHEMBL10801716 | 0.87 | TOP2A (0.54) | TOP2ANQO1CYP19A1SMN1; SMN2MEN1 | |
| SCHEMBL10818789 | 0.87 | TOP2A (0.69) | TOP2ANQO1CYP19A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5447950-A | Anthra[1,9-c,d]pyrazol-6-(2H)-ones useful for treating anaerobic bacterial infections | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1995-09-05 | — | — | US | disclosed |
| EP-0579647-A1 | ANTI-CANCER COUMPOUNDS | BTG INTERNATIONAL LIMITED (GB) | 1994-01-26 | — | — | EP | disclosed |
| WO-1992018485-A1 | ANTI-CANCER COUMPOUNDS | BRITISH TECHNOLOGY GROUP LTD. (GB) | 1992-10-29 | — | — | WO | disclosed |