Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 8/20 | 0.75 |
| ▸ | LMNA | P02545 | 2/20 | 0.75 |
| ▸ | NT5E | P21589 | 2/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.75 |
| ▸ | GLI1 | P08151 | 3/20 | 0.66 |
| ▸ | RELA | Q04206 | 1/20 | 0.66 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.66 |
| ▸ | RORC | P51449 | 2/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.66 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.66 |
| ▸ | ALB | P02768 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.66 |
| ▸ | DPP4 | P27487 | 1/20 | 0.66 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.66 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.66 |
| ▸ | MGAM | O43451 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | SI | P14410 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9131455 | 0.91 | GPBAR1 (0.62) | GPBAR1LMNANT5ESMN1; SMN2GLI1 | |
| SCHEMBL21435925 | 0.90 | GPBAR1 (0.84) | GPBAR1LMNANT5ESMN1; SMN2GLI1 | |
| SCHEMBL21435975 | 0.86 | GPBAR1 (0.71) | GPBAR1LMNANT5ESMN1; SMN2GLI1 | |
| Betunolic Acid SCHEMBL14111993 | 0.85 | GPBAR1 (1.00) | GPBAR1LMNANT5ESMN1; SMN2GLI1 | |
| Betunolic Acid SCHEMBL13814592 | 0.85 | GPBAR1 (1.00) | GPBAR1LMNANT5ESMN1; SMN2GLI1 | |
| Betunolic Acid SCHEMBL13573800 | 0.85 | GPBAR1 (1.00) | GPBAR1LMNANT5ESMN1; SMN2GLI1 | |
| Betunolic Acid SCHEMBL13098064 | 0.85 | GPBAR1 (1.00) | GPBAR1LMNANT5ESMN1; SMN2GLI1 | |
| Betunolic Acid SCHEMBL13908772 | 0.85 | GPBAR1 (1.00) | GPBAR1LMNANT5ESMN1; SMN2GLI1 | |
| Betunolic Acid SCHEMBL14397742 | 0.85 | GPBAR1 (1.00) | GPBAR1LMNANT5ESMN1; SMN2GLI1 | |
| Betunolic Acid SCHEMBL10062172 | 0.85 | GPBAR1 (1.00) | GPBAR1LMNANT5ESMN1; SMN2GLI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5468888-A | Lupane derivatives, their preparation and the pharmaceutical compositions which contain them | RHONE-POULENC RORER S.A. (FR) | 1995-11-21 | — | — | US | disclosed |