Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | INHA | P05111 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | TRPV2 | Q9Y5S1 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9130547 | 1.00 | TRPV1 (0.39) | TRPV1CNR1CNR2PPARGTRPA1 | |
| SCHEMBL9632981 | 0.96 | TRPV1 (0.41) | TRPV1CNR1CNR2PPARGTRPA1 | |
| SCHEMBL9632985 | 0.96 | TRPV1 (0.41) | TRPV1CNR1CNR2PPARGTRPA1 | |
| SCHEMBL9130490 | 0.87 | SQLE (0.47) | TRPV1CNR1CNR2PPARGTRPA1 | |
| SCHEMBL9130491 | 0.87 | SQLE (0.47) | TRPV1CNR1CNR2PPARGTRPA1 | |
| SCHEMBL9633255 | 0.85 | SQLE (0.49) | TRPV1CNR1CNR2PPARGTRPA1 | |
| SCHEMBL9634087 | 0.83 | PPARG (0.41) | TRPV1CNR1CNR2PPARGTRPA1 | |
| SCHEMBL9634094 | 0.83 | PPARG (0.41) | TRPV1CNR1CNR2PPARGTRPA1 | |
| SCHEMBL9633219 | 0.81 | TRPV1 (0.34) | TRPV1CNR1CNR2PPARGTRPA1 | |
| SCHEMBL9632567 | 0.81 | GRIN2D (0.35) | SLC6A2SLC6A4SLC6A3S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428028-A | Method for lowering cholesterol employing a phosphonomethylphosphinate squalene synthetase inhibitor | E. R. SQUIBB & SONS, INC. (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0513761-A2 | Bisphosphonate squalene synthetase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| US-5157027-A | Anticholesterol agents | E. R. SQUIBB & SONS, INC. (US) | 1992-10-20 | — | — | US | disclosed |