Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | LITAF | Q99732 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.38 |
| ▸ | KRAS | P01116 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | MLYCD | O95822 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9132418 | 0.82 | PDE4B (0.45) | KCNH2PDE4ATNFLITAFDDB1 | |
| SCHEMBL9130617 | 0.82 | PDE4A (0.37) | PDE4ADDB1CRBN | |
| SCHEMBL9129878 | 0.81 | PMM2 (0.38) | KCNH2PDE4ADDB1CRBN | |
| SCHEMBL9132364 | 0.81 | FEN1 (0.50) | KCNH2PDE4ADDB1CRBN | |
| SCHEMBL30438257 | 0.81 | MAPT (0.49) | PDE4ADDB1CRBN | |
| SCHEMBL6009928 | 0.81 | MAPT (0.49) | PDE4ADDB1CRBN | |
| SCHEMBL9129320 | 0.80 | DDB1 (0.37) | KCNH2PDE4ADDB1CRBN | |
| SCHEMBL9129767 | 0.78 | PDE4A (0.53) | PDE4AMET | |
| SCHEMBL10660620 | 0.76 | TNF (0.38) | KCNH2PDE4AMAPK8TNFLITAF | |
| SCHEMBL10659551 | 0.76 | EPHB4 (0.38) | KCNH2PDE4AMAPK8TNFLITAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5439916-A | Antiallergens,-inflammatory and -ulcer agents; hypotensive agents; immunosuppressants; skin disorders | SCHERING CORPORATION (US) | 1995-08-08 | — | — | US | disclosed |
| US-5126352-A | Antiallergy, antiinflammatory, antiulcer, hypotensive, antibody inhibitors | SCHERING CORPORATION (US) | 1992-06-30 | — | — | US | disclosed |
| US-5116840-A | Antiulcer, antiinflammatory, hypotensive, immunosuppressants | SCHERING CORPORATION (US) | 1992-05-26 | — | — | US | disclosed |
| EP-0229823-B1 | POLYCYCLIC QUINOLINE, NAPHTHYRIDINE AND PYRAZINOPYRIDINE DERIVATIVES | SCHERING CORPORATION (US) | 1991-09-25 | — | — | EP | disclosed |
| US-4988705-A | Antiallergens and -inflammatory agents; hypotensive agents immunological suppression; hyperproliferative skin disorders such as psoriasis | SCHERING CORPORATION (US) | 1991-01-29 | — | — | US | disclosed |
| US-4810708-A | ANTIALLERGY, IMMUNOSUPPRESSIVE | SCHERING CORPORATION (US) | 1989-03-07 | — | — | US | disclosed |