Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 4/20 | 0.61 |
| ▸ | RARB | P10826 | 1/20 | 0.55 |
| ▸ | RARG | P13631 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.52 |
| ▸ | RXRA | P19793 | 3/20 | 0.50 |
| ▸ | RXRB | P28702 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | RXRG | P48443 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3497043 | 0.88 | MAPT (0.52) | SRD5A2TSHRKMT2AALDH1A1 | |
| SCHEMBL6040838 | 0.84 | MAPT (0.48) | SRD5A2MEN1KMT2ANR1H4EPHX2 | |
| SCHEMBL9577287 | 0.83 | SRD5A2 (0.57) | SRD5A2RARBRARGTP53TSHR | |
| SCHEMBL3637376 | 0.83 | KMT2A (0.67) | SRD5A2RARBRARGTP53TSHR | |
| SCHEMBL11852341 | 0.83 | SRD5A2 (0.42) | SRD5A2RARBRARGMEN1CYP1A2 | |
| SCHEMBL31510753 | 0.83 | KMT2A (0.50) | SRD5A2TSHRMEN1CYP1A2KMT2A | |
| SCHEMBL5325439 | 0.83 | SRD5A2 (0.42) | SRD5A2RARBRARGMEN1CYP1A2 | |
| SCHEMBL927353 | 0.82 | SRD5A2 (0.61) | SRD5A2RARBRARGTP53TSHR | |
| SCHEMBL71433 | 0.81 | SRD5A2 (0.65) | SRD5A2RARBRARGTP53TSHR | |
| SCHEMBL11772204 | 0.81 | SRD5A2 (0.65) | SRD5A2RARBRARGTP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368295-B1 | PROCESS FOR THE MANUFACTURE OF PHENYLACETIC ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-04-12 | — | — | EP | disclosed |
| US-5468888-A | Lupane derivatives, their preparation and the pharmaceutical compositions which contain them | RHONE-POULENC RORER S.A. (FR) | 1995-11-21 | — | — | US | disclosed |