Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.47 |
| ▸ | TUBB | P07437 | 1/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.47 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.47 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.47 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.47 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.47 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9129643 | 0.92 | KDM4C (0.56) | PARP1MAPTPKMKDM4EMEN1 | |
| SCHEMBL9131594 | 0.85 | TNKS2 (0.62) | PARP1MAPTPKMKDM4EMEN1 | |
| SCHEMBL7418316 | 0.84 | PARP1 (0.68) | PARP1MAPTKMT2AALDH1A1TUBB4A | |
| SCHEMBL9327417 | 0.83 | PARP1 (0.66) | PARP1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL13111952 | 0.83 | PARP1 (0.66) | PARP1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7415916 | 0.81 | PARP1 (0.63) | PARP1MAPTKDM4ETUBB4ATUBB | |
| SCHEMBL11376990 | 0.81 | PARP1 (0.63) | PARP1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL9376967 | 0.81 | PARP1 (0.63) | PARP1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8805356 | 0.80 | MAPT (0.79) | MAPTPKMKDM4EMEN1KMT2A | |
| SCHEMBL168776 | 0.80 | PARP1 (1.00) | PARP1MEN1KMT2ATNKS2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5441959-A | Hypotensive agents; treating congestive heart failure and glaucoma,inhibiting restenosis | MERCK & CO., INC. (US) | 1995-08-15 | — | — | US | disclosed |