Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LPO | P22079 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21341793 | 0.77 | KDM4E (0.43) | KDM4EGAACYP1A2CA1ALDH1A1 | |
| SCHEMBL4478455 | 0.73 | HPGD (0.46) | KDM4EGAACYP1A2CA1ALDH1A1 | |
| SCHEMBL4771259 | 0.70 | HPGD (0.44) | KDM4EGAACYP1A2CA1ALDH1A1 | |
| SCHEMBL22817640 | 0.70 | KDM4E (0.38) | KDM4EGAACYP1A2CA1ALDH1A1 | |
| SCHEMBL15459460 | 0.70 | HSD17B10 (0.43) | KDM4EGAACYP1A2CA1ALDH1A1 | |
| SCHEMBL28170050 | 0.70 | KDM4E (0.38) | KDM4EGAACYP1A2CA1ALDH1A1 | |
| SCHEMBL9455125 | 0.70 | GAA (0.38) | KDM4EGAACYP1A2CA1ALDH1A1 | |
| SCHEMBL26967993 | 0.70 | PDE3B (0.40) | KDM4EGAACYP1A2CA1ALDH1A1 | |
| SCHEMBL3188766 | 0.69 | CYP1A2 (0.45) | KDM4EGAACYP1A2ALDH1A1ADORA1 | |
| SCHEMBL10686284 | 0.69 | NOTUM (0.45) | KDM4EGAACYP1A2CA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5380730-A | Angiotensin antagonist | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-01-10 | — | — | US | disclosed |
| US-5236936-A | Treating hypertension, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |
| US-5198439-A | Hypotensive agents, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-03-30 | — | — | US | disclosed |
| EP-0499416-A2 | Pyridine compounds as angiotensin II antagonists, processes for their preparation and pharmaceutical compositions containing them | ZENECA LIMITED (GB) | 1992-08-19 | — | — | EP | disclosed |
| US-5130318-A | Hypotensive agents and for treatment of congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-14 | — | — | US | disclosed |
| CN-1055925-A | Pyridine derivate and preparation method thereof | ICI PLC (GB) | 1991-11-06 | — | — | CN | disclosed |
| EP-0453210-A2 | Pyridine derivatives | ZENECA LIMITED (GB) | 1991-10-23 | — | — | EP | disclosed |