Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 10/20 | 0.61 |
| ▸ | JAK3 | P52333 | 10/20 | 0.61 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.44 |
| ▸ | BUB1 | O43683 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 4/20 | 0.40 |
| ▸ | JAK1 | P23458 | 3/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL913611 | 1.00 | IRAK4 (0.61) | IRAK4JAK3MAP4K1BUB1JAK2 | |
| SCHEMBL915211 | 0.86 | IRAK4 (0.72) | IRAK4JAK3MAP4K1JAK2JAK1 | |
| SCHEMBL915210 | 0.86 | IRAK4 (0.72) | IRAK4JAK3MAP4K1JAK2JAK1 | |
| SCHEMBL913822 | 0.84 | IRAK4 (0.68) | IRAK4JAK3MAP4K1JAK2JAK1 | |
| SCHEMBL913825 | 0.84 | IRAK4 (0.68) | IRAK4JAK3MAP4K1JAK2JAK1 | |
| SCHEMBL913113 | 0.83 | IRAK4 (0.80) | IRAK4JAK3MAP4K1JAK2JAK1 | |
| SCHEMBL913115 | 0.83 | IRAK4 (0.80) | IRAK4JAK3MAP4K1JAK2JAK1 | |
| SCHEMBL3716312 | 0.81 | JAK3 (0.43) | IRAK4JAK3BUB1JAK2JAK1 | |
| SCHEMBL913865 | 0.80 | JAK3 (0.49) | IRAK4JAK3JAK2JAK1TYK2 | |
| SCHEMBL913864 | 0.80 | JAK3 (0.49) | IRAK4JAK3JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130137673-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | US | claimed |
| US-20110005947-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | US | claimed |
| US-8853230-B2 | Inhibitors of JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2014-10-07 | — | — | US | disclosed |
| US-20130137673-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | US | disclosed |
| US-8367689-B2 | Inhibitors of JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-02-05 | — | — | US | disclosed |
| US-20110005947-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137673-A1 | INHIBITORS OF JAK | JAK1, JAK2, JAK3 | IRAK4 48/4885JAK3 3/4885MAP4K1 76/4885 |
| US-20110005947-A1 | INHIBITORS OF JAK | JAK1, JAK2, JAK3 | IRAK4 48/4885JAK3 3/4885MAP4K1 76/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.