SCHEMBL9137129

SCHEMBL9137129

O=C(O)CN1C=Cc2ccccc2C1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.53
CA12 O43570 1/20 0.40
CA9 Q16790 1/20 0.40
KDM4E B2RXH2 4/20 0.39
ALOX15 P16050 1/20 0.39
TSHR P16473 1/20 0.39
SIRT1 Q96EB6 1/20 0.39
HSD17B3 P37058 1/20 0.38
KMT2A Q03164 4/20 0.36
MEN1 O00255 2/20 0.36
POLB P06746 2/20 0.36
MAPT P10636 2/20 0.36
TDP1 Q9NUW8 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
APEX1 P27695 1/20 0.36
ESR1 P03372 1/20 0.35
ESR2 Q92731 1/20 0.35
NOTUM Q6P988 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1128540 0.86 HDAC3 (0.50) HDAC3KDM4EALOX15KMT2AMEN1
Bromide SCHEMBL19031267 0.84 HDAC3 (0.51) HDAC3KDM4EALOX15TSHRSIRT1
SCHEMBL30306313 0.81 HDAC3 (0.55) HDAC3KDM4EHSD17B3KMT2AMEN1
SCHEMBL28139257 0.81 HDAC3 (0.48) HDAC3TSHRHSD17B3ESR1ESR2
Hydrazine SCHEMBL28954453 0.79 HDAC3 (0.53) HDAC3KDM4EHSD17B3KMT2AMEN1
SCHEMBL9379346 0.79 HDAC3 (0.74) HDAC3KDM4EALOX15TSHRSIRT1
SCHEMBL25435570 0.79 HDAC3 (0.51) HDAC3HSD17B3ESR1ESR2NOTUM
SCHEMBL9474777 0.79 HDAC3 (0.46) HDAC3KDM4ETSHRHSD17B3TDP1
Hydrochloric Acid SCHEMBL11699382 0.78 HDAC3 (0.46) HDAC3KDM4EALOX15TSHRKMT2A
Bromide SCHEMBL9772108 0.78 HDAC3 (0.45) HDAC3HSD17B3ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5389661-A Treats hypertension, heart failure, glaucoma and hyperaldosteronism WARNER-LAMBERT COMPANY (US) 1995-02-14 US disclosed
US-5322950-A Treating hypertension, hyperaldosteronism, glaucoma, heart failure WARNER-LAMBERT COMPANY (US) 1994-06-21 US disclosed